抗原或丝裂原刺激的人外周血T细胞产生组胺释放淋巴因子。
Production of a histamine-releasing lymphokine by antigen- or mitogen-stimulated human peripheral T cells.
作者信息
Sedgwick J D, Holt P G, Turner K J
出版信息
Clin Exp Immunol. 1981 Aug;45(2):409-18.
Abstract
Human peripheral blood leucocytes (PBL), cultured in the presence of mitogen or antigen, yielded supernatants which contained a factor with histamine-releasing activity (HRA). This factor, analogous to the putative lymphokine HRA described by Thueson et al. (1979a), was shown to promote the rapid release of histamine from PBL preparations containing basophils. HRA production by PBL in response to co-culture with the skin test antigens Candida and SK-SD was shown to reflect the in vivo immune status of the PBL donor. Experiments with isolated cell populations from PBL implicated T cells as the prime source of HRA, production of the factor being macrophage-dependent. HRA activity failed to synergize anti-IgE-mediated histamine release, and was not species-restricted.
摘要
在有丝分裂原或抗原存在的情况下培养的人外周血白细胞（PBL）产生的上清液中含有一种具有组胺释放活性（HRA）的因子。该因子类似于Thueson等人（1979年a）描述的假定淋巴因子HRA，已证明它能促进含有嗜碱性粒细胞的PBL制剂中组胺的快速释放。PBL与皮肤试验抗原白色念珠菌和SK - SD共培养时产生HRA，这反映了PBL供体的体内免疫状态。对PBL中分离的细胞群体进行的实验表明，T细胞是HRA的主要来源，该因子的产生依赖于巨噬细胞。HRA活性不能协同抗IgE介导的组胺释放，且无种属限制。
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