Grindal A B, Suter C, Martinez A J
Ann Neurol. 1977 Apr;1(4):371-7. doi: 10.1002/ana.410010408.
Alpha-pattern coma denotes the association of a comatose state with an electroencephalogram consisting predominately of alpha-frequency activity. Over the past three years we have studied 24 such cases: 14 following cardiopulmonary arrest, 6 following respiratory arrest, and 3 following brainstem infarction. Of the 9 patients who survived, only 1 had a significant neurological deficit. It was found that: (1) alpha-pattern coma can result from a variety of neurological insults; (2) a significant proportion of patients survive, often with little or no deficit; (3) clinical evidence of intact brainstem function implies a favorable outcome; (4) the electroencephalogram was similar in survivors and nonsurvivors and did not differentiate diffuse cerebral dysfunction from focal brainstem disease; and (5) neuropathological studies demonstrated diffuse cortical as well as brainstem changes.
α波型昏迷是指昏迷状态与主要由α波频率活动组成的脑电图相关联。在过去三年里，我们研究了24例此类病例：14例发生在心肺骤停后，6例发生在呼吸骤停后，3例发生在脑干梗死后。在9名存活的患者中，只有1名有明显的神经功能缺损。研究发现：（1）α波型昏迷可由多种神经损伤引起；（2）相当一部分患者存活下来，通常几乎没有或没有功能缺损；（3）脑干功能完整的临床证据意味着预后良好；（4）存活者和非存活者的脑电图相似，无法区分弥漫性脑功能障碍和局灶性脑干疾病；（5）神经病理学研究显示有弥漫性皮质以及脑干改变。
