Weck P K, Apperson S, May L, Stebbing N
J Gen Virol. 1981 Nov;57(Pt 1):233-7. doi: 10.1099/0022-1317-57-1-233.
Five human interferon-alpha (leukocyte) subtypes derived from genes cloned in Escherichia coli have been compared for their ability to induce antiviral activity against vesicular stomatitis virus infection of various mammalian cell cultures. These interferons, designated LeIF-A (IFN-alpha 2), -B, -C, -D (IFN-alpha 1) and LeIF-F, show different relative activities when assayed on human, bovine, hamster, mouse, rabbit and monkey cell lines. As with a natural human buffy-coat interferon-alpha preparation, three subtypes (LeIF-B, -C and -D) showed considerable activity on RK-13 rabbit cells, but two (LeIF-D and -F) also showed some activity on mouse L-929 cells. Of the five interferon subtypes examined, LeIF-F demonstrated the highest degree of species specificity.
对从克隆于大肠杆菌的基因中获得的五种人α-干扰素（白细胞）亚型诱导抗病毒活性的能力进行了比较，该抗病毒活性针对各种哺乳动物细胞培养物中的水疱性口炎病毒感染。这些干扰素，命名为LeIF-A（IFN-α2）、-B、-C、-D（IFN-α1）和LeIF-F，在人、牛、仓鼠、小鼠、兔和猴细胞系上进行检测时显示出不同的相对活性。与天然人血沉棕黄层α-干扰素制剂一样，三种亚型（LeIF-B、-C和-D）在RK-13兔细胞上显示出相当高的活性，但两种（LeIF-D和-F）在小鼠L-929细胞上也显示出一些活性。在所检测的五种干扰素亚型中，LeIF-F表现出最高程度的种属特异性。
