Babiuk L A, Rouse B T
Intervirology. 1977;8(4):250-6. doi: 10.1159/000148900.
The antiviral and cell growth inhibition spectra of bovine and human interferons are described. The antiviral activity of type II interferon in heterologous cells far exceeded that of the corresponding type I interferon. Antiviral activity of bovine type II interferon parallels cell growth inhibition activity both in thermal inactivation kinetics as well as in the rate of synthesis. Furthermore, the spectrum of antiviral activity against heterologous cells was the same as that seen for cell growth inhibition suggesting that one molecule may mediate both effects. The therapeutic implications of type II interferon prepared in animals for use in human medicine are discussed briefly.
本文描述了牛干扰素和人干扰素的抗病毒及细胞生长抑制谱。II型干扰素在异源细胞中的抗病毒活性远远超过相应的I型干扰素。牛II型干扰素的抗病毒活性在热失活动力学以及合成速率方面均与细胞生长抑制活性相似。此外，其对异源细胞的抗病毒活性谱与细胞生长抑制谱相同，这表明可能由一个分子介导这两种效应。文中还简要讨论了在动物体内制备的II型干扰素用于人类医学的治疗意义。
