Asbrink E, Hovmark A
Acta Derm Venereol. 1981;61(5):417-21.
We report the clinical variations and the duration of prodromal symptoms in 20 patients with bullous pemphigoid. Nearly two-thirds of the patients had prodromal symptoms. THe duration of the prodromal eruptions was up to 6 weeks if papular and/or urticarial and up to 2 years if eczematous, before the blisters appeared. Evidently longer prodromal periods were found in the present study than in earlier investigations. It is not known when in the course of the disease the direct immunofluorescence will be positive. Two of our patients were immunofluorescence-positive 1 and 2 weeks respectively before the blisters appeared. A common clinical manifestation in this study was vesicles on palms and/or soles. These eruptions, particularly as an early symptom, may cause misinterpretation in patients with bullous pemphigoid.
我们报告了20例大疱性类天疱疮患者的临床变异情况及前驱症状持续时间。近三分之二的患者有前驱症状。在水疱出现之前，丘疹和/或荨麻疹样前驱皮疹的持续时间长达6周，湿疹样的则长达2年。显然，本研究中发现的前驱期比早期调查中的更长。目前尚不清楚在疾病过程中直接免疫荧光何时会呈阳性。我们的两名患者在水疱出现前分别于1周和2周时免疫荧光呈阳性。本研究中一种常见的临床表现是手掌和/或脚底出现水疱。这些皮疹，尤其是作为早期症状时，可能会导致大疱性类天疱疮患者出现误诊。
