Mózsik G, Nagy L, Tárnok F, Kutas J
Acta Med Acad Sci Hung. 1981;38(2):129-34.
Separation and measurement of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenine-adenosine, lipid phosphates (lipid P), ribonucleic acid (RNA), deoxyribonucleic acid (DNA), further of Mg2+-dependent, total (Mg2+-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPases was carried out in control (non-ulcerated) and ulcerated (mucosa up to 2.0 cm around the ulcer) jejunal mucosa of 11 patients with chronic jejunal ulcer, who had undergone a Billroth II gastric resection for duodenal ulcer. The levels of ATP, ADP, AMP, sum of ATP + ADP + AMP, lipid-P, RNA (related to 1.0 mg DNA) and the activity of Mg2+-dependent, total (Mg2+-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPase (related to 1.0 mg membrane protein) were significantly higher in the lacerated jejunal mucosa than in the control one. The results indicate that (1) no circulatory damage can be found in the ulcerated jejunal mucosa; (2) a cellular hyperactivity (increased ATP breakdown and increased ATP resynthesis, increased RNA and lipid synthesis) occurs in the ulcerated jejunal mucosa; (3) the biochemical structure of cells differs significantly in the control and the ulcerated jejunal mucosa.
对11例因十二指肠溃疡接受毕罗Ⅱ式胃切除术的慢性空肠溃疡患者，在其对照（未溃疡）和溃疡（溃疡周围2.0 cm以内的黏膜）空肠黏膜中进行了三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、一磷酸腺苷（AMP）、腺嘌呤 - 腺苷、脂质磷酸盐（脂质P）、核糖核酸（RNA）、脱氧核糖核酸（DNA）以及进一步的镁离子依赖性、总（镁离子依赖性加钠钾离子依赖性）和钠钾离子依赖性ATP酶的分离与测定。在撕裂的空肠黏膜中，ATP、ADP、AMP、ATP + ADP + AMP总和、脂质P、RNA（与1.0 mg DNA相关）以及镁离子依赖性、总（镁离子依赖性加钠钾离子依赖性）和钠钾离子依赖性ATP酶活性（与1.0 mg膜蛋白相关）水平均显著高于对照黏膜。结果表明：（1）在溃疡的空肠黏膜中未发现循环损伤；（2）在溃疡的空肠黏膜中发生了细胞活性亢进（ATP分解增加、ATP再合成增加、RNA和脂质合成增加）；（3）对照和溃疡空肠黏膜中细胞的生化结构存在显著差异。
