Inhibition by somatostatin of pancreatic juice and enzyme secretion and gallbladder contraction induced by secretin, cholecystokinin-pancreozymin and carbachol administration.

The effect of somatostatin on secretin-, CCK-pancreozymin-and-carbachol-stimulated pancreatic secretion was studied in eight healthy volunteers. In all instances there was a significant reduction in duodenal secretory volume after secretin without any change in bicarbonate concentration. CCK-parcreozymin and carbachol stimulated volume and enzyme secretion were significantly inhibited and gallbladder contraction was abolished by somatostatin. In three volunteers a reversible hypercoagulation during infusion of 200 mug/h cyclic somatostatin has been observed. Somatostatin inhibited the CCK-pancreozymin stimulated pancreatic enzyme secretion of anaesthesized rats.