Tewari S G, Tyagi S P, Vaid A K
Gastroenterol Jpn. 1981;16(5):441-6. doi: 10.1007/BF02774515.
Serum amylase (SA) and its isoenzymes were studied in 9 control cases and 26 cases of Viral Hepatitis (VH). A significant rise in SA level was found in VH cases (Mean value--287.15 + 100.64) as compared to control cases (Mean value--155.56 + 28.57). The value was markedly increased in 8 cases with hepatic encephalopathy (Mean value--388 + 57.21). Isoenzymes of SA were estimated in all the cases by means of polyacrylamide gel electrophoresis and a direct saccharogenic assay of amylase activity. Besides two regular peaks (Pancreatic and Salivary fractions) a third peak (Slowest of all) was noticed in 4 out of 9 control cases (44.5%) and 19 out of 26 cases of VH (73.1%). Out of 8 cases who developed hepatic encephalopathy during the course, 7 had this peak (87.5%). SA levels and its isoenzymes level correlated well with the extent of hepatic damage (SGPT and Serum bilirubin levels). The possibility of hepatic origin of the third peak has been discussed.
对9例对照病例和26例病毒性肝炎（VH）患者的血清淀粉酶（SA）及其同工酶进行了研究。与对照病例（平均值为155.56±28.57）相比，VH病例的SA水平显著升高（平均值为287.15±100.64）。8例肝性脑病患者的SA值明显升高（平均值为388±57.21）。采用聚丙烯酰胺凝胶电泳和淀粉酶活性直接糖化测定法对所有病例的SA同工酶进行了测定。除了两个常规峰（胰腺和唾液部分）外，在9例对照病例中有4例（44.5%）和26例VH病例中有19例（73.1%）出现了第三个峰（所有峰中最慢的）。在病程中发生肝性脑病的8例患者中，有7例出现了这个峰（87.5%）。SA水平及其同工酶水平与肝损伤程度（SGPT和血清胆红素水平）密切相关。文中讨论了第三个峰源于肝脏的可能性。
