Singal D P, Blajchman M A, Naipaul N, Heddle N
Hum Immunol. 1981 Dec;3(4):325-35. doi: 10.1016/0198-8859(81)90068-9.
We have studied the role of MNSs determinants in the primed lymphocyte test (PLT). The data demonstrate that incompatibility associated with the M or N antigens causes HLA-restricted proliferative responses in PLT. Responses to the M or N determinants required the presence of the same HLA-A antigen(s) on both the stimulator and the responder cells. No effects of S or s incompatibility were observed in this test. This is the first report of lymphocyte proliferative responses to "minor" alloantigens that require corecognition of the MHC determinants. These observations suggest possible new biological functions of these blood group antigens.
我们研究了MNSs决定簇在致敏淋巴细胞试验（PLT）中的作用。数据表明，与M或N抗原相关的不相容性会在PLT中引发HLA限制的增殖反应。对M或N决定簇的反应要求刺激细胞和反应细胞上存在相同的HLA - A抗原。在该试验中未观察到S或s不相容性的影响。这是首次报道对“次要”同种异体抗原的淋巴细胞增殖反应需要MHC决定簇的共同识别。这些观察结果提示了这些血型抗原可能的新生物学功能。
