与逆转录病毒致癌基因类似的细胞基因在人类肿瘤细胞中被转录。
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells.
作者信息
Eva A, Robbins K C, Andersen P R, Srinivasan A, Tronick S R, Reddy E P, Ellmore N W, Galen A T, Lautenberger J A, Papas T S, Westin E H, Wong-Staal F, Gallo R C, Aaronson S A
出版信息
Nature. 1982 Jan 14;295(5845):116-9. doi: 10.1038/295116a0.
DOI:10.1038/295116a0
PMID:6173755
Abstract
Polyadenylated RNAs of certain human tumour cell lines are shown to contain transcripts related to the cell-derived transforming onc genes of molecularly cloned primate, murine or avian transforming retrovirus genomes. Thus, analogues of retroviral transforming genes are both present and frequently expressed in human neoplastic cells.
摘要
某些人类肿瘤细胞系的多聚腺苷酸化RNA显示含有与分子克隆的灵长类、鼠类或禽类转化逆转录病毒基因组的细胞衍生转化癌基因相关的转录本。因此，逆转录病毒转化基因的类似物在人类肿瘤细胞中既存在且经常表达。
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