大鼠迟发型反应中嗜酸性粒细胞增多的实验性产生。
The experimental production of increased eosinophils in rat late-phase reactions.
作者信息
Lemanske R F, Kaliner M A
出版信息
Immunology. 1982 Mar;45(3):561-8.
The effects of peripheral eosinophilia on the intensity, kinetics and cellular characteristics of rat cutaneous late-phase reactions (LPR) have been investigated. Two distinct methods of inducing peripheral eosinophilia did not alter either the intensity or the kinetics of LPR produced by the intradermal injection of anti-IgE, Compound 48/80, or isolated mast cell granules. Hypereosinophilic animals exhibited increased numbers of tissue eosinophils in LPR tissue sites which correlated with the elevations in their respective peripheral eosinophil counts; however, the absolute number of eosinophils present, although significant, was not impressive (less than 10% of total). Our data suggest that, although rat LPR can be modulated to involve increased tissue eosinophils by increasing the numbers of peripheral blood eosinophils, no effects of these procedures on altering either the intensity or the kinetics of these reactions can be appreciated.
已对外周血嗜酸性粒细胞增多对大鼠皮肤迟发型反应（LPR）的强度、动力学及细胞特征的影响进行了研究。两种诱导外周血嗜酸性粒细胞增多的不同方法，均未改变皮内注射抗IgE、48/80化合物或分离的肥大细胞颗粒所产生的LPR的强度或动力学。嗜酸性粒细胞增多的动物在LPR组织部位的组织嗜酸性粒细胞数量增加，这与它们各自外周血嗜酸性粒细胞计数的升高相关；然而，尽管存在的嗜酸性粒细胞绝对数量显著，但并不惊人（不到总数的10%）。我们的数据表明，虽然通过增加外周血嗜酸性粒细胞数量可调节大鼠LPR，使其涉及更多组织嗜酸性粒细胞，但这些操作对改变这些反应的强度或动力学均无明显影响。
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