Ribeiro-Ayeh J, Walther A, Horrig C
Monatsschr Kinderheilkd. 1982 Jan;130(1):30-5.
Since 1978, four patients with Ewing's sarcoma have been on a treatment-regimen based on the T-6 and T-2 Protocols according to Rosen. Preoperative chemotherapy produced tumor regression and thus enabled surgical resection in three cases. In the first case, radiation therapy was felt necessary because the surgical resection was performed after the first course of the T-6 Protocol and cells suspected to be malignant were found on histological examination of the resected tumor. The experience prompted us to refrain from using radiation therapy in the next two cases but to conduct the surgical resection after two cycles of T-6 Protocol. Here, histological examinations of the resected tumors showed no evidence of malignant cells. The fourth patient had a pathologic fracture in addition to the tumor. In this case, it was possible, by means of chemotherapy to heal the fracture and also to produce a regression of the tumor. Because of the radiation morbidity, we believe that it is a notable progress in the treatment of Ewing's sarcoma if radiation therapy can be avoided.
自1978年以来，4例尤因肉瘤患者一直按照罗森的T - 6和T - 2方案接受治疗。术前化疗使肿瘤缩小，从而使3例患者能够进行手术切除。在第一例中，由于在T - 6方案的第一个疗程后进行了手术切除，且在切除肿瘤的组织学检查中发现了疑似恶性的细胞，因此认为有必要进行放射治疗。这一经验促使我们在接下来的两例中不使用放射治疗，而是在T - 6方案的两个周期后进行手术切除。在此，切除肿瘤的组织学检查未发现恶性细胞的证据。第四例患者除肿瘤外还发生了病理性骨折。在这种情况下，通过化疗有可能治愈骨折并使肿瘤缩小。由于放射治疗的发病率，我们认为如果能够避免放射治疗，这在尤因肉瘤的治疗中是一个显著的进展。
