Imai K, Pellegrino M A, Ng A K, Ferrone S
Scand J Immunol. 1981 Nov;14(5):529-35.
Cultured human lymphoid WI-L2 cells incubated with human leucocyte interferon (final concentration 500 and 2000 U/ml) for 16 h at 37 degrees C acquire increased susceptibility to complement and cell-dependent lysis mediated by monoclonal antibodies to HLA-A,B antigens and to human beta 2-microglobulin but do not change in their susceptibility to immune lysis mediated by monoclonal antibodies to human Ia-like antigens. Changes in susceptibility to immune lysis of interferon-treated lymphoid cells are likely to reflect changes in antigen density, since binding assays with monoclonal antibodies and quantitative absorption assays with alloantisera have shown that the expression of HLA-A,B antigens and beta 2-microglobulin is significantly increased on interferon-treated lymphoid cells, whereas that of Ia-like antigens in not changed.
在37℃下，将培养的人淋巴样WI-L2细胞与人白细胞干扰素（终浓度500和2000 U/ml）一起孵育16小时后，其对补体以及由针对HLA-A、B抗原和人β2-微球蛋白的单克隆抗体介导的细胞依赖性裂解的敏感性增加，但对由针对人Ia样抗原的单克隆抗体介导的免疫裂解的敏感性没有变化。干扰素处理的淋巴样细胞对免疫裂解敏感性的变化可能反映了抗原密度的变化，因为用单克隆抗体进行的结合试验和用同种抗血清进行的定量吸收试验表明，干扰素处理的淋巴样细胞上HLA-A、B抗原和β2-微球蛋白的表达显著增加，而Ia样抗原的表达没有变化。
