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利用单克隆抗体(Q5/13)免疫吸附剂纯化人Ia样抗原的免疫功能亚群。

Purification of immunologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent.

作者信息

Quaranta V, Walker L E, Pellegrino M A, Ferrone S

出版信息

J Immunol. 1980 Oct;125(4):1421-5.

PMID:6157732
Abstract

Serologic and immunochemical asays have shown that the monoclonal antibody Q5/13 recognizes an antigenic determinant expressed on a subset of human Ia-like antigens. Testing with a panel of HLA typed B lymphoid cells has shown that this determinant is different from those defining the serologic polymorphism of HLA-DR antigens. The monoclonal antibody Q5/13 has been used to purify subsets of human Ia-like antigens, which are immunologically functional. These reagents should facilitate the characterization of structural and functional properties of human Ia-like antigens.

摘要

血清学和免疫化学分析表明,单克隆抗体Q5/13识别在一部分人Ia样抗原上表达的一个抗原决定簇。用一组HLA分型的B淋巴细胞进行检测表明,这个决定簇不同于那些定义HLA-DR抗原血清学多态性的决定簇。单克隆抗体Q5/13已被用于纯化具有免疫功能的人Ia样抗原亚群。这些试剂应有助于对人Ia样抗原的结构和功能特性进行表征。

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