Sentsui H, Kono Y
Am J Vet Res. 1981 Nov;42(11):1949-52.
The serologic relationships between 6 strains of equine infectious anemia (EIA) viruses were investigated by hemagglutination-inhibition (HI) tests. Cross HI tests, using sera from horses in the early stage of infection, revealed that all strains were inhibited only by homologous strain antisera and that HI antibody was always detectable before virus-neutralizing antibody. In the later stages of infection, both homologous and heterologous HI antibodies were detected in a sera of most of the horses, and the order of appearance of heterologous HI antibodies was random in 2 horses inoculated with the same virus strain. The viruses sequentially isolated from 1 horse had serologically the same hemagglutinating antigenicity to their parent virus. These results indicate that hemagglutinating antigens of EIA virus were type specific, but different from the antigens detectable by neutralization. The possible role of EIA virus hemagglutinin and HI antibody in causing periodic anemia is discussed.
通过血凝抑制（HI）试验研究了6株马传染性贫血（EIA）病毒之间的血清学关系。使用感染早期马匹的血清进行交叉HI试验，结果显示所有毒株仅被同源毒株抗血清所抑制，并且在病毒中和抗体出现之前总能检测到HI抗体。在感染后期，大多数马匹的血清中检测到同源和异源HI抗体，在接种同一病毒株的2匹马中，异源HI抗体的出现顺序是随机的。从1匹马中依次分离出的病毒与其亲本病毒在血清学上具有相同的血凝抗原性。这些结果表明，EIA病毒的血凝抗原具有型特异性，但与中和试验可检测的抗原不同。文中讨论了EIA病毒血凝素和HI抗体在引起周期性贫血中可能发挥的作用。
