Strombeck D R, Farver T, Kaneko J J
Am J Vet Res. 1981 Nov;42(11):1966-70.
To determine the usefulness of information provided by measurement of serum amylase activity in the evaluation of dogs for pancreatitis, the relationship of amylase activity to lipase activity in 713 paired serum samples was investigated by statistical analysis. Little change in mean amylase concentration was found until lipase values exceeded 800 U/L. The ranges of amylase activity (mean +/- 2 SD) were essentially the same for dogs with no pancreatitis (0 to 100 U of lipase activity/L) as for dogs with a high probability for the disease (700 to 799 U of lipase activity/L), 0 to 4,029 U/L and 857 to 4,869 U/L, respectively. Pathologic findings from biopsy and necropsy reports from 92 dogs for which serum lipase determinations were done indicated that serum lipase increased not only with pancreatitis, but also with other medical problems, such as renal and hepatic disease. It was concluded that determination of serum amylase activity without knowledge of serum lipase activity was of little value to diagnose pancreatitis. High amylase activity was not specific for pancreatitis and low amylase activity could not rule out the disease. The results of this study also showed that low serum lipase values almost always eliminated the possibility of pancreatitis and that high values were often, but not always, diagnostic for pancreatitis.
为了确定血清淀粉酶活性测定所提供的信息在犬胰腺炎评估中的作用，通过统计分析研究了713对血清样本中淀粉酶活性与脂肪酶活性的关系。在脂肪酶值超过800 U/L之前，淀粉酶平均浓度几乎没有变化。对于无胰腺炎的犬（脂肪酶活性为0至100 U/L）和高度疑似该病的犬（脂肪酶活性为700至799 U/L），淀粉酶活性范围（均值±2标准差）基本相同，分别为0至4,029 U/L和857至4,869 U/L。对92只进行了血清脂肪酶测定的犬的活检和尸检报告的病理结果表明，血清脂肪酶不仅随胰腺炎升高，还随其他医学问题升高，如肾脏和肝脏疾病。得出的结论是，在不知道血清脂肪酶活性的情况下测定血清淀粉酶活性对诊断胰腺炎价值不大。高淀粉酶活性并非胰腺炎所特有，低淀粉酶活性也不能排除该病。本研究结果还表明，低血清脂肪酶值几乎总能排除胰腺炎的可能性，而高值虽常可诊断胰腺炎，但并非总是如此。
