McCarty G A, Rice J R, Fetter B F, Pisetsky D S
Arch Pathol Lab Med. 1982 Apr;106(4):196-9.
The serologic and clinical features of a 32-year-old women with coexistent systemic lupus erythematosus and lymphoma were studied. A cervical node biopsy specimen demonstrated nodular, poorly differentiated lymphocytic lymphoma; subsequent development of polyarthralgias prompted evaluation for connective-tissue disease, and a high titer of antinuclear antibody was found. Immunochemical studies proved that this antibody was directed to the Sm antigen, a serologic finding highly specific for systemic lupus erythematosus. This antibody has been maintained throughout the course of the patient's disease, characterized by persistent lymphadenopathy, pleuropericarditis, arthritis, hypocomplementemia, hyperglobulinemia, and a slight elevation of titers of anti-DNA antibody. The course of the lymphoproliferative disorder has been consistent with that of an indolent non-Hodgkin's lymphoma. In sera from other patients with lymphoproliferative disorders, anti-Sm antibody was not found. These findings emphasize the importance of establishing the antigenic specificity of antinuclear antibodies detected in the sera of patients with neoplasia.
对一名同时患有系统性红斑狼疮和淋巴瘤的32岁女性的血清学和临床特征进行了研究。颈部淋巴结活检标本显示为结节性、低分化淋巴细胞淋巴瘤；随后出现的多关节痛促使对结缔组织病进行评估，结果发现抗核抗体滴度很高。免疫化学研究证明，这种抗体针对的是Sm抗原，这是一种对系统性红斑狼疮具有高度特异性的血清学发现。在患者整个病程中，这种抗体一直存在，其特点是持续性淋巴结病、胸膜心包炎、关节炎、补体血症、高球蛋白血症以及抗DNA抗体滴度略有升高。淋巴增生性疾病的病程与惰性非霍奇金淋巴瘤一致。在其他淋巴增生性疾病患者的血清中未发现抗Sm抗体。这些发现强调了确定肿瘤患者血清中检测到的抗核抗体抗原特异性的重要性。
