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1
Natural killing of cytomegalovirus-infected fibroblasts by human mononuclear leucocytes.人单核白细胞对巨细胞病毒感染的成纤维细胞的自然杀伤作用。
Clin Exp Immunol. 1981 Dec;46(3):484-92.
2
Natural killing (NK) of cytomegalovirus (CMV)-infected fibroblasts: a comparison between two strains of CMV, uninfected fibroblasts, and K562 cells.巨细胞病毒（CMV）感染的成纤维细胞的自然杀伤（NK）作用：两种CMV毒株、未感染的成纤维细胞和K562细胞之间的比较。
J Med Virol. 1985 Jul;16(3):233-44. doi: 10.1002/jmv.1890160304.
3
Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts.干扰素和白细胞介素2对巨细胞病毒感染的成纤维细胞自然杀伤作用的影响。
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4
Lysis of human cytomegalovirus infected fibroblasts by natural killer cells: demonstration of an interferon-independent component requiring expression of early viral proteins and characterization of effector cells.自然杀伤细胞对人巨细胞病毒感染的成纤维细胞的裂解作用：一种不依赖干扰素的成分的证明，该成分需要早期病毒蛋白的表达以及效应细胞的特性分析
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5
NK recognition of cytomegalovirus-infected endothelial cells depends on viral replication and MHC class I expression.自然杀伤细胞对巨细胞病毒感染的内皮细胞的识别取决于病毒复制和主要组织相容性复合体I类分子的表达。
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Lysis of human arterial smooth muscle cells infected with herpesviridae by peripheral blood mononuclear cells: implications for atherosclerosis.外周血单核细胞对感染疱疹病毒科的人动脉平滑肌细胞的裂解作用：对动脉粥样硬化的影响。
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Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus.人巨细胞病毒低传代临床分离株感染的成纤维细胞的自然杀伤作用。
Clin Exp Immunol. 1988 Jul;73(1):11-6.
8
Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA.自然杀伤细胞对巨细胞病毒（CMV）感染细胞的裂解作用与病毒诱导的细胞表面淋巴细胞功能相关抗原-3（LFA-3）表达变化有关，而与CMV诱导的细胞表面I类人白细胞抗原（HLA）下调无关。
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J Virol Methods. 1996 Jan;56(1):77-84. doi: 10.1016/0166-0934(95)01954-5.
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Inability of interferon to protect virus-infected cells against lysis by natural killer (NK) cells correlates with NK cell-mediated antiviral effects in vivo.干扰素无法保护病毒感染的细胞免受自然杀伤（NK）细胞的裂解，这与NK细胞在体内介导的抗病毒作用相关。
J Immunol. 1985 Nov;135(5):3537-41.

引用本文的文献

1
Relationship between expression of herpes simplex virus glycoproteins and susceptibility of target cells to human natural killer activity.单纯疱疹病毒糖蛋白的表达与靶细胞对人自然杀伤活性的敏感性之间的关系。
J Exp Med. 1983 May 1;157(5):1544-61. doi: 10.1084/jem.157.5.1544.
2
Molecular biology and immunology of cytomegalovirus.巨细胞病毒的分子生物学与免疫学
Biochem J. 1987 Jan 15;241(2):313-24. doi: 10.1042/bj2410313.
3
Requirement for HLA-DR+ accessory cells in natural killing of cytomegalovirus-infected fibroblasts.巨细胞病毒感染的成纤维细胞自然杀伤中HLA - DR +辅助细胞的需求
J Exp Med. 1986 Jul 1;164(1):180-95. doi: 10.1084/jem.164.1.180.
4
Cytomegalovirus (CMV)-specific lysis of CMV-infected target cells can be mediated by both NK-like and virus-specific cytotoxic T lymphocytes.巨细胞病毒（CMV）感染的靶细胞的巨细胞病毒特异性裂解可由自然杀伤样细胞和病毒特异性细胞毒性T淋巴细胞介导。
Clin Exp Immunol. 1985 Jul;61(1):80-9.
5
Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus.人巨细胞病毒低传代临床分离株感染的成纤维细胞的自然杀伤作用。
Clin Exp Immunol. 1988 Jul;73(1):11-6.
6
Effects of interferons and interleukin 2 on natural killing of cytomegalovirus-infected fibroblasts.干扰素和白细胞介素2对巨细胞病毒感染的成纤维细胞自然杀伤作用的影响。
Clin Exp Immunol. 1987 Feb;67(2):372-82.
7
Innate immunity during Equid herpesvirus 1 (EHV-1) infection.马疱疹病毒1型（EHV-1）感染期间的天然免疫
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Human T-cell cultures from virus-sensitized donors can mediate virus-specific and HLA-restricted cell lysis.来自病毒致敏供体的人T细胞培养物可介导病毒特异性和HLA限制性细胞裂解。
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Lymphocyte blastogenesis and interferon production in adult human leukocyte cultures stimulated with cytomegalovirus antigens.用巨细胞病毒抗原刺激成人人类白细胞培养物中的淋巴细胞增殖及干扰素产生。
Infect Immun. 1980 Oct;30(1):17-22. doi: 10.1128/iai.30.1.17-22.1980.
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Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation.人白细胞干扰素治疗骨髓移植后巨细胞病毒肺炎的毒性与疗效
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Purification of human T and B lymphocytes.人T淋巴细胞和B淋巴细胞的纯化
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Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes.神经氨酸酶处理的绵羊红细胞与人类T淋巴细胞的结合增强。
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An in vitro method for study of human lymphocyte cytotoxicity against mumps-virus-infected target cells.一种研究人淋巴细胞对腮腺炎病毒感染靶细胞细胞毒性的体外方法。
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Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.通过将淋巴细胞与肿瘤衍生细胞或病毒转化细胞共培养诱导的抗病毒活性。干扰素增强人自然杀伤细胞活性以及对靶细胞裂解敏感性的拮抗抑制作用。
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Induction and kinetics of natural killer cells in humans following interferon therapy.干扰素治疗后人体自然杀伤细胞的诱导及动力学
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人单核白细胞对巨细胞病毒感染的成纤维细胞的自然杀伤作用。

Natural killing of cytomegalovirus-infected fibroblasts by human mononuclear leucocytes.

作者信息

Starr S E, Garrabrant T

出版信息

Clin Exp Immunol. 1981 Dec;46(3):484-92.

PMID:6175462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536312/
Abstract

The ability of human peripheral blood mononuclear (MN) cells to lyse uninfected and cytomegalovirus (CMV) infected human fibroblasts was determined in a 51Cr-release assay. Maximal release was obtained with 6-day infected fibroblasts incubated with MN cells for 24 hr. A linear relationship existed between E/T ratios of 12.5:1 to 100:1 and lysis of CMV-infected targets. Donor immune status had no effect on the magnitude of killing of infected or uninfected targets. Killing was mediated by non-B, predominantly non-T, Fc receptor-bearing cells. Preincubation of effector cells with interferon enhanced killing of both CMV-infected and uninfected fibroblasts, but infected targets were more effectively killed. These results indicated a possible role for natural killer cells in recovery from CMV infection.

摘要

采用铬-51释放试验测定人外周血单个核（MN）细胞对未感染及巨细胞病毒（CMV）感染的人成纤维细胞的裂解能力。将6天感染的成纤维细胞与MN细胞孵育24小时可获得最大释放量。效应细胞与靶细胞（E/T）比例在12.5:1至100:1之间时，与CMV感染靶细胞的裂解呈线性关系。供体免疫状态对感染或未感染靶细胞的杀伤程度无影响。杀伤由非B细胞、主要是非T细胞且带有Fc受体的细胞介导。效应细胞与干扰素预孵育可增强对CMV感染及未感染成纤维细胞的杀伤，但对感染靶细胞的杀伤更有效。这些结果表明自然杀伤细胞在从CMV感染中恢复过程中可能发挥作用。