人巨细胞病毒低传代临床分离株感染的成纤维细胞的自然杀伤作用。
Natural killing of fibroblasts infected with low-passage clinical isolates of human cytomegalovirus.
作者信息
Bandyopadhyay S, Oh S H, Michelson S, Miller D S, Virelizier J L, Starr S E
机构信息
Department of Pediatrics, Joseph Stokes Jr. Research Institute, Children's Hospital of Philadelphia, Pennsylvania.
出版信息
Clin Exp Immunol. 1988 Jul;73(1):11-6.
Fibroblasts infected with most low-passage clinical isolates of human cytomegalovirus (CMV) were as susceptible to lysis by human natural killer (NK) cells as high passage AD-169-infected fibroblasts. NK lysis occurred despite the absence of detectable CMV-specific late membrane antigen(s) on the majority of the target cells infected with most of the low passage strains. The magnitude of NK lysis of different CMV-infected target cells did not correlate with their ability to induce IFN-alpha. NK cell-mediated lysis of cells infected with low-passage clinical isolates of CMV required both NK cells and HLA-DR+ accessory cells, as previously shown for AD-169-infected target cells.
感染大多数低代临床分离株人巨细胞病毒（CMV）的成纤维细胞，与感染高代AD - 169的成纤维细胞一样，对人自然杀伤（NK）细胞的裂解敏感。尽管在感染大多数低代毒株的大多数靶细胞上未检测到可检测的CMV特异性晚期膜抗原，但仍发生NK裂解。不同CMV感染靶细胞的NK裂解程度与其诱导IFN-α的能力无关。如先前对感染AD - 169的靶细胞所示，NK细胞介导的对感染CMV低代临床分离株的细胞的裂解需要NK细胞和HLA - DR +辅助细胞。
Zotero 插件