Harrell S A, Maheshwari R K, Mohanty S B, Friedman R M
Am J Vet Res. 1982 Apr;43(4):565-8.
Human lymphoblastoid interferon (IFN) had an antiviral activity in bovine embryonic kidney cells that resulted in the release of vesicular stomatitis virus (VSV) particles with decreased infectivity. The inhibition was dose dependent and the cells were highly sensitive to human IFN. Examination of the proteins of VSV released from bovine cells after IFN treatment showed a reduction in the glycoprotein. Electron microscopic studies revealed a large number of VSV particles with characteristic spike-like surface projections released from nontreated cells. There was a reduction in the number of mature virions produced in IFN-treated cells and the virions lacked the characteristic surface projections.
人淋巴母细胞干扰素（IFN）在牛胚胎肾细胞中具有抗病毒活性，可导致感染性降低的水疱性口炎病毒（VSV）颗粒释放。这种抑制作用呈剂量依赖性，且细胞对人IFN高度敏感。对IFN处理后从牛细胞中释放的VSV蛋白质进行检测，发现糖蛋白减少。电子显微镜研究显示，未处理的细胞释放出大量具有特征性尖刺状表面突起的VSV颗粒。IFN处理的细胞中产生的成熟病毒粒子数量减少，且这些病毒粒子缺乏特征性的表面突起。
