5-氟尿嘧啶在各种人体正常组织和肿瘤组织中的代谢。
Metabolism of 5-fluorouracil in various human normal and tumor tissues.
作者信息
Maehara Y, Nagayama S, Okazaki H, Nakamura H, Shirasaka T, Fujii S
出版信息
Gan. 1981 Dec;72(6):824-7.
The metabolism of 5-fluorouracil (5-FU) in tumors and normal tissues of humans was investigated in vitro. Phosphorylation of 5-FU was faster in tumor tissues than in normal tissues. Phosphorylating activity with 2-deoxy-alpha-D-ribose 1-phosphate (dRiblP) and ATP as cofactors was more active than that with alpha D-ribose 1-phosphate (RiblP) and ATP, or 5-phospho-alpha-D-ribosyldiphosphate (PPRibP) as cofactors. Phosphorylating activity in squamous cell carcinoma of the lung was similar to that in adenocarcinomas. Degradation of 5-FU was much faster in the liver than in other tissues including tumor tissues.
在体外研究了5-氟尿嘧啶（5-FU）在人体肿瘤组织和正常组织中的代谢情况。5-FU在肿瘤组织中的磷酸化速度比正常组织快。以2-脱氧-α-D-核糖1-磷酸（dRiblP）和ATP作为辅因子的磷酸化活性比以α-D-核糖1-磷酸（RiblP）和ATP或5-磷酸-α-D-核糖二磷酸（PPRibP）作为辅因子时更活跃。肺鳞状细胞癌中的磷酸化活性与腺癌中的相似。5-FU在肝脏中的降解速度比包括肿瘤组织在内的其他组织快得多。
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