Teillaud J L, Crevat D, Chardon P, Kalil J, Goujet-Zalc C, Mahouy G, Vaiman M, Fellous M, Pious D
Immunogenetics. 1982;15(4):377-84. doi: 10.1007/BF00364261.
The cross-reactivity of several monoclonal antibodies recognizing monomorphic determinants of human HLA-A, B, C, and DR antigens and human beta 2-microglobulin (beta 2m) has been studied on peripheral blood leukocytes in 24 different species. An monoclonal HLA-A-, B-, and C-specific antibody and four monoclonal HLA-DR-specific antibodies cross-reacted with cells from all the primate species tested. Furthermore, antibodies HLA-DR-specific were positive with peripheral blood leukocytes (PBL) from cows, goats, sheep, horses, and dogs. Two monoclonal beta 2m-specific antibodies, which were positive with PBL from certain primates, also reacted with cells from cows, goats, sheep, horses, and dogs. Two other beta 2-m-specific antibodies reacted only with PBL from chimpanzees. No reaction could be detected with all our reagents in other classes tested (birds, reptiles, amphibians, and Teleostei).
已在24种不同物种的外周血白细胞上研究了几种识别人类HLA - A、B、C和DR抗原以及人类β2 - 微球蛋白（β2m）单态决定簇的单克隆抗体的交叉反应性。一种HLA - A、B和C特异性单克隆抗体以及四种HLA - DR特异性单克隆抗体与所有测试的灵长类动物的细胞发生交叉反应。此外，HLA - DR特异性抗体对来自牛、山羊、绵羊、马和狗的外周血白细胞（PBL）呈阳性反应。两种对某些灵长类动物的PBL呈阳性反应的β2m特异性单克隆抗体，也与来自牛、山羊、绵羊、马和狗的细胞发生反应。另外两种β2 - m特异性抗体仅与黑猩猩的PBL发生反应。在测试的其他类别（鸟类、爬行动物、两栖动物和硬骨鱼）中，我们所有的试剂均未检测到反应。
