用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10致敏的无反应小鼠淋巴细胞产生的免疫抑制因子。IV. 同种异体无反应供体和受体之间不存在品系限制。
Immunosuppressive factors from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10. IV. Lack of strain restrictions among allogeneic, nonresponder donors and recipients.
作者信息
Kapp J A
出版信息
J Exp Med. 1978 Apr 1;147(4):997-1006. doi: 10.1084/jem.147.4.997.
Abstract
The synthetic terpolymer of L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) fails to stimulate development of GAT-specific antibody responses in nonresponder mice but stimulates development of GAT-specific suppressor T cells that inhibit the development of normal anti-GAT plaque-forming cell responses to GAT complexed to methylated bovine serum albumin (MBSA). Extracts from lymphoid cells of GAT-primed but not control, nonresponder (DBA/1) mice contain a T-cell factor (GAT-TsF) that also specifically suppresses responses to GAT-MBSA by normal syngeneic spleen cells. The experiments reported in this communication demonstrate that: (a) extracts from all GAT-primed nonresponder mice tested contain GAT-TsF; (b) non-H-2 genes do not restrict the production of GAT-TsF; (c) all nonresponder strains of mice regardless of their non-H-2 genes are suppressed by GAT-TsF from all other strains bearing the nonresponder H-2p,q,s haplotypes; (d) suppression of GAT-MBSA responses by both syngeneic and allogeneic nonresponder spleen cells is mediated by a molecule encoded by the H-2 gene complex; and (e) both syngeneic and allogeneic nonresponder mice are suppressed by purified GAT-TsF that lacks immunoreactive GAT.
摘要
L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的合成三元共聚物无法刺激无反应小鼠产生GAT特异性抗体反应，但能刺激GAT特异性抑制性T细胞的发育，这些抑制性T细胞会抑制正常的抗GAT斑块形成细胞对与甲基化牛血清白蛋白（MBSA）复合的GAT的反应。来自经GAT致敏的小鼠而非对照无反应（DBA/1）小鼠的淋巴细胞提取物含有一种T细胞因子（GAT-TsF），该因子也能特异性抑制同基因正常脾细胞对GAT-MBSA的反应。本通讯中报道的实验表明：（a）所有测试的经GAT致敏的无反应小鼠的提取物都含有GAT-TsF；（b）非H-2基因不限制GAT-TsF的产生；（c）所有无反应小鼠品系，无论其非H-2基因如何，都被来自所有携带无反应H-2p、q、s单倍型的其他品系的GAT-TsF所抑制；（d）同基因和异基因无反应脾细胞对GAT-MBSA反应的抑制是由H-2基因复合体编码的分子介导的；（e）同基因和异基因无反应小鼠都被缺乏免疫反应性GAT的纯化GAT-TsF所抑制。
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Immunosuppressive factors from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10. IV. Lack of strain restrictions among allogeneic, nonresponder donors and recipients.用L-谷氨酸60-L-丙氨酸30-L-酪氨酸10致敏的无反应小鼠淋巴细胞产生的免疫抑制因子。IV. 同种异体无反应供体和受体之间不存在品系限制。
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