岩沙海葵毒素既能诱导也能抑制大鼠肥大细胞释放组胺。

Palytoxin both induces and inhibits the release of histamine from rat mast cells.

作者信息

Chhatwal G S, Ahnert-Hilger G, Beress L, Habermann E

出版信息

Int Arch Allergy Appl Immunol. 1982;68(2):97-100. doi: 10.1159/000233075.

Abstract

Palytoxin (PTX) is a potent releaser of histamine from rat mast cells. The concentration response curve is bell-shaped with its range between 0.05 ng/ml and 5 micrograms/ml and its maximum at 50 ng/ml. The release of histamine by PTX is specific because (a) heat-inactivated (50 degrees C) mast cells are insensitive to PTX, and (b) extracellular calcium is essential. Removal of extracellular potassium as well as the presence of borate shifts the curve to the left by factor of 10. At higher concentrations (5 micrograms/ml), PTX inhibits the release of histamine due to compound 48/80, MCD-peptide, Con-A, ionophore A-23187, and PTX itself.

摘要

刺尾鱼毒素（PTX）是一种能有效促使大鼠肥大细胞释放组胺的物质。浓度-反应曲线呈钟形，范围在0.05纳克/毫升至5微克/毫升之间，最大值出现在50纳克/毫升处。PTX引起的组胺释放具有特异性，原因如下：（a）经热灭活（50摄氏度）的肥大细胞对PTX不敏感；（b）细胞外钙至关重要。去除细胞外钾以及存在硼酸盐会使曲线向左移动10倍。在较高浓度（5微克/毫升）时，PTX会抑制由化合物48/80、MCD肽、刀豆蛋白A、离子载体A-23187以及PTX自身所导致的组胺释放。