毒胡萝卜素和毒胡萝卜icin激活参与炎症反应细胞的能力。
The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response.
作者信息
Ali H, Christensen S B, Foreman J C, Pearce F L, Piotrowski W, Thastrup O
出版信息
Br J Pharmacol. 1985 Jul;85(3):705-12. doi: 10.1111/j.1476-5381.1985.tb10567.x.
Abstract
The ability of thapsigargin and thapsigargicin to activate mast cells and leukocytes has been investigated. The thapsigargin-induced histamine release from rat peritoneal mast cells was found to be dependent on the concentration of thapsigargin, the purity of the mast cell preparations, and the number of mast cells in suspension. Thapsigargin induced histamine release from human basophil leukocytes. Thapsigargin induced beta-glucuronidase and lysozyme release from human neutrophil leukocytes. Thapsigargin caused a release of histamine from mesentery, lung, and heart mast cells of the rat, but only to a minor extent from the corresponding guinea-pig cells. Thapsigargicin induced histamine release from mesentery, lung, and heart mast cells of the rat at concentrations from 0.1 microM but provoked only a release from the corresponding guinea-pig cells in the concentration-range 0.16 to 1.6 microM. Thapsigargin increased the cytoplasmic free calcium level in intact human blood platelets at concentrations from 3.0 nM.
摘要
已对毒胡萝卜素和毒胡萝卜icin激活肥大细胞和白细胞的能力进行了研究。发现毒胡萝卜素诱导大鼠腹膜肥大细胞释放组胺取决于毒胡萝卜素的浓度、肥大细胞制剂的纯度以及悬浮液中肥大细胞的数量。毒胡萝卜素诱导人嗜碱性白细胞释放组胺。毒胡萝卜素诱导人中性粒细胞释放β-葡萄糖醛酸酶和溶菌酶。毒胡萝卜素导致大鼠肠系膜、肺和心脏肥大细胞释放组胺，但从相应的豚鼠细胞释放的程度较小。毒胡萝卜icin在浓度为0.1微摩尔时诱导大鼠肠系膜、肺和心脏肥大细胞释放组胺，但在浓度范围为0.16至1.6微摩尔时仅引起相应豚鼠细胞释放。毒胡萝卜素在浓度为3.0纳摩尔时增加完整人血小板中的细胞质游离钙水平。
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