Metaxotou-Mavromati A D, Antonopoulou H K, Laskari S S, Tsiarta H K, Ladis V A, Kattamis C A
Pediatrics. 1982 Jun;69(6):734-8.
To study the developmental pattern of hemoglobin F (HbF) during the first two years of life, levels of HbF were estimated in two groups of infants: 117 normal infants and 98 heterozygotes for beta-thalassemia, all aged between 1 and 24 months. The results may be summarized as follows: (1) Levels of HbF in beta-thalassemia heterozygotes were significantly higher than those of normal infants of the same age (P less than .01). (2) A reference curve for the decline of HbF in infants with beta-thalassemia trait was established to facilitate the diagnosis of heterozygotes during this period of life. (3) Hemoglobin A2 (HbA2) was also higher in beta-thalassemia heterozygotes than in normal infants of the same age. HbA2 increases with increasing age, reaching normal adult values at age 5 to 6 months. It is postulated that the higher level of HbF in heterozygous infants during the first two years of life is associated with the presence of the beta-thalassemia gene, which influences the increased synthesis of HbF in red cell.
为研究出生后头两年血红蛋白F（HbF）的发育模式，对两组婴儿的HbF水平进行了评估：117名正常婴儿和98名β地中海贫血杂合子婴儿，年龄均在1至24个月之间。结果总结如下：（1）β地中海贫血杂合子婴儿的HbF水平显著高于同龄正常婴儿（P<0.01）。（2）建立了β地中海贫血特征婴儿HbF下降的参考曲线，以利于在此生命阶段对杂合子进行诊断。（3）β地中海贫血杂合子婴儿的血红蛋白A2（HbA2）也高于同龄正常婴儿。HbA2随年龄增长而增加，在5至6个月时达到正常成人水平。据推测，杂合子婴儿在出生后头两年HbF水平较高与β地中海贫血基因的存在有关，该基因影响红细胞中HbF合成增加。
