Collan Y, Ranta H, Vartio T, Perheentupa J, Raeste A M
Scand J Dent Res. 1982 Feb;90(1):20-8. doi: 10.1111/j.1600-0722.1982.tb01520.x.
Four patients with hereditary hyperplasia of the gingiva were studied. Biopsy samples of gingival tissue contained subepithelial loose connective tissue with thick rounded fibroblasts or dense collagen-rich connective tissue with thin fibroblasts, which appeared to be inactive. These two types of fibroblasts differed in electron microscopy. Alcian blue-staining of intercellular material in various MgCl2 concentrations was similar in hyperplastic and control samples. Collagen from the hyperplastic gingiva appeared to be more mature than normal, based on the presence of stable, nonreducible cross lines. An investigation of growth hormone secretion and a treatment trial suggested that the growth retardation observed in earlier studies was due to normal variation in growth rates or (in one patient) to hypopituitarism associated with birth in breech presentation.
对4例遗传性牙龈增生患者进行了研究。牙龈组织活检样本包含上皮下疏松结缔组织，其中有成纤维细胞粗大圆润，或富含致密胶原的结缔组织，其中成纤维细胞细小，看起来不活跃。这两种成纤维细胞在电子显微镜下有所不同。在不同氯化镁浓度下，增生样本和对照样本中细胞间物质的阿尔辛蓝染色相似。基于稳定的、不可还原的交联线的存在，增生牙龈中的胶原蛋白似乎比正常的更成熟。一项生长激素分泌调查和治疗试验表明，早期研究中观察到的生长发育迟缓是由于生长速率的正常变化，或（在一名患者中）是由于臀位出生相关的垂体功能减退。
