Buchner A, Calderon S, Ramon Y
J Periodontol. 1977 Feb;48(2):101-4. doi: 10.1902/jop.1977.48.2.101.
A study was made of a series of 302 consecutive cases of localized hyperplastic lesions of the gingiva (epulides). The lesions were classified into five groups: pyogenic granuloma, calcifying fibroblastic granuloma, fibrous hyperplasia, peripheral giant cell granuloma and denture hyperplasia. The study indicates that there are some differences in age and sex distribution as well as in location between the different histological groups. Pyogenic granuloma was found to be the most common lesion on the gingiva. Pyogenic granuloma and calcifying fibroblastic granuloma occur in younger patients more often than fibrous hyperplasia, and thus may represent a stage in the development of fibrous hyperplasia. Denture hyperplasia occurs predominantly in females and it is suggested that its formation may be affected by hormonal alterations in the menopause.
对302例连续的牙龈局限性增生性病变（龈瘤）进行了研究。病变分为五组：化脓性肉芽肿、钙化性纤维性肉芽肿、纤维增生、外周巨细胞肉芽肿和义齿性增生。研究表明，不同组织学组在年龄、性别分布以及部位上存在一些差异。化脓性肉芽肿是牙龈最常见的病变。化脓性肉芽肿和钙化性纤维性肉芽肿比纤维增生更常发生于年轻患者，因此可能代表纤维增生发展的一个阶段。义齿性增生主要发生于女性，提示其形成可能受绝经后激素改变的影响。
