大鼠离体胃黏膜对五肽胃泌素和乙酰甲胆碱反应时组胺分泌增加。
Increased histamine-output from the isolated gastric mucosa of the rat in response to pentagastrin and methacholine.
作者信息
Main I H, Pearce J B
出版信息
Br J Pharmacol. 1982 May;76(1):51-9. doi: 10.1111/j.1476-5381.1982.tb09190.x.
Abstract
1 A rat isolated gastric mucosal preparation was used to monitor histamine output and acid secretion during stimulation by different secretagogues. 2 In non-stimulated preparations, spontaneous histamine output decreased over 450 min. 3 Stimulation of secretion with 4 (5)-methylhistamine or dibutyryl cyclic adenosine 3'5'-monophosphate (db cyclic AMP) and theophylline did not influence histamine output. 4 Pentagastrin, gastrin and methacholine increased both acid secretion and histamine output. Pentagastrin and gastrin mobilized six times more histamine and relation to acid secretion than did methacholine. 5 Spontaneous histamine output and secretagogue-induced increases were unaffected by changes in external Ca2+ (0.0 to 7.2 mM) or Mg2+ (1.2 to 4.8 mM). 6 These results support the hypothesis that mucosal histamine plays a more important role in the action of gastrin than of cholinomimetics on the parietal cell.
摘要
- 使用大鼠离体胃黏膜制备物监测不同促分泌剂刺激期间的组胺释放和胃酸分泌。2. 在未受刺激的制备物中，自发组胺释放在450分钟内减少。3. 用4（5）-甲基组胺或二丁酰环腺苷3'，5'-单磷酸（db环磷酸腺苷）和茶碱刺激分泌不影响组胺释放。4. 五肽胃泌素、胃泌素和乙酰甲胆碱增加胃酸分泌和组胺释放。与乙酰甲胆碱相比，五肽胃泌素和胃泌素释放的组胺量是其六倍，且与胃酸分泌相关。5. 自发组胺释放和促分泌剂诱导的增加不受细胞外Ca2 +（0.0至7.2 mM）或Mg2 +（1.2至4.8 mM）变化的影响。6. 这些结果支持以下假设：黏膜组胺在胃泌素对壁细胞的作用中比拟胆碱药发挥更重要的作用。
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本文引用的文献
1
Extracellular calcium and cholinergic stimulation of isolated canine parietal cells.细胞外钙与离体犬壁细胞的胆碱能刺激
J Clin Invest. 1981 Jul;68(1):270-8. doi: 10.1172/jci110243.
2
Localization of cells containing and forming histamine in the gastric mucosa of the rat.大鼠胃黏膜中含组胺及形成组胺的细胞的定位
Exp Cell Res. 1967 Aug;47(1):108-15. doi: 10.1016/0014-4827(67)90214-5.
3
A modified fluorometric procedure for tissue histamine and its distribution in various animals.一种改良的组织组胺荧光测定法及其在各种动物体内的分布。
J Pharmacol Exp Ther. 1969 Apr;166(2):285-90.
4
Effect of antrectomy on gastric histidine decarboxylase activity in the rat.胃窦切除术对大鼠胃组织中组氨酸脱羧酶活性的影响。
Am J Physiol. 1969 May;216(5):1051-3. doi: 10.1152/ajplegacy.1969.216.5.1051.
5
The role of endogenous gastrin in the activation of gastric histidine decarboxylase in the rat. Effect of antrectomy and vagal denervation.内源性胃泌素在大鼠胃组氨酸脱羧酶激活中的作用。胃窦切除术和迷走神经切断术的影响。
Eur J Pharmacol. 1970 Sep 1;12(1):94-103. doi: 10.1016/0014-2999(70)90033-6.
6
The role of the antrum and the vagus nerve in the formation of gastric mucosal histamine.胃窦和迷走神经在胃黏膜组胺形成中的作用。
J Physiol. 1969 Nov;205(2):275-88. doi: 10.1113/jphysiol.1969.sp008964.
7
Active ion transport by isolated gastric mucosae of rat and guinea pig.大鼠和豚鼠离体胃黏膜的主动离子转运
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J Physiol. 1972 Oct;226(2):431-52. doi: 10.1113/jphysiol.1972.sp009992.
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