甲硫米特对大鼠离体全胃中胃泌素、乙酰胆碱及二丁酰环磷腺苷酸刺激的胃酸分泌的影响。
The effect of metiamide on acid secretion stimulated by gastrin, acetylcholine and dibutyryl cyclic adenosine 3',5'-monophosphate in the isolated whole stomach of the rat.
作者信息
Bunce K T, Parsons M E, Rollings N A
出版信息
Br J Pharmacol. 1976 Sep;58(1):149-56. doi: 10.1111/j.1476-5381.1976.tb07704.x.
Abstract
1 An isolated stomach preparation from immature rats is described. The lumen of the stomach was perfused and the hydrogen ion activity of the perfusate recorded continuously. 2 The preparation gave dose-dependent responses to gastrin, acetylcholine and dibutyryl cyclic adenosine 3',5'-monophosphate and these responses were readily reversed on washing out the agonist. 3 The acid secretory response to gastrin was inhibited by metiamide at concentrations of 10(-5) M and 3 X 10(-5)M. 4 The acid secretory responses to acetylcholine and dibutyryl cyclic adenosine 3',5'-monophosphate were not inhibited by concentrations of metiamide up to 10(-3) M. 5 These findings are discussed in relation to the role of histamine in the control of gastric acid secretion.
摘要
描述了一种来自未成熟大鼠的离体胃制备方法。胃腔被灌注，灌注液的氢离子活性被连续记录。
该制备物对胃泌素、乙酰胆碱和二丁酰环磷腺苷3',5'-单磷酸呈现剂量依赖性反应，并且在洗去激动剂后这些反应很容易逆转。
在浓度为10(-5) M和3×10(-5) M时，甲硫咪胺抑制了对胃泌素的酸分泌反应。
浓度高达10(-3) M的甲硫咪胺未抑制对乙酰胆碱和二丁酰环磷腺苷3',5'-单磷酸的酸分泌反应。
结合组胺在胃酸分泌控制中的作用对这些发现进行了讨论。
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