Nothdurft W, Steinbach K H, Ross W M, Fliedner T M
Cell Tissue Kinet. 1982 May;15(3):331-40. doi: 10.1111/j.1365-2184.1982.tb01051.x.
The relationship between the increase in the blood CFUc concentration after intravenous injection of dextran sulphate (DS) and the pre-existing levels of spontaneously circulating CFUc was studied in dogs. After 15 mg DS/kg body weight the CFUc numbers per ml blood rose by a factor of 3.7 over the pre-injection values, from 78 +/- 11 (SEM) to 359 +/- 50, in normal dogs, and increased by a factor of 3.9 in 0.84-Gy-r-irradiated animals which had a reduced initial CFUc concentration per ml, from 35 +/- 8 to 116 +/- 43. The injection of 20 mg DS/kg body weight into unirradiated dogs caused an increase, by a factor of 11.5, of the pre-injection CFUc concentration, from 101 +/- 20 to 921 +/- 106. On the basis of the mobilization curves for individual dogs, a significant correlation was found between the normal blood CFUc value and the number of CFUc mobilized by DS for both dose levels. From the descending part of the mobilization curves obtained after 15 mg DS/kg body weight, kinetic parameters of canine circulating CFUc were derived. The mean blood transit time (t) was 1.4 +/- 0.5 hr and the half time (T/2) was 1.0 +/- 0.4 hr.
在犬类中研究了静脉注射硫酸葡聚糖（DS）后血液中集落形成单位（CFUc）浓度的增加与预先存在的自发循环CFUc水平之间的关系。在正常犬中，静脉注射15mg DS/kg体重后，每毫升血液中的CFUc数量比注射前的值增加了3.7倍，从78±11（标准误）增加到359±50；在初始每毫升CFUc浓度降低的0.84-Gy-r照射动物中，CFUc数量增加了3.9倍，从35±8增加到116±43。向未照射的犬静脉注射20mg DS/kg体重导致注射前CFUc浓度增加了11.5倍，从101±20增加到921±106。根据个体犬的动员曲线，发现在两个剂量水平下，正常血液CFUc值与DS动员的CFUc数量之间存在显著相关性。从静脉注射15mg DS/kg体重后获得的动员曲线的下降部分，得出犬循环CFUc的动力学参数。平均血液 transit 时间（t）为1.4±0.5小时，半衰期（T/2）为1.0±0.4小时。 （注：“transit”可能是“转运”之类的专业术语，这里保留英文，因为不确定准确的中文专业表述）
