实验性变应性神经炎和变应性脑脊髓炎中针对P2和P1髓鞘抗原的抗体

Antibodies to P2 and P1 myelin antigens in experimental allergic neuritis and allergic encephalomyelitis.

作者信息

Zweiman B, Moskovitz A R, Rostami A, Lisak R P, Pleasure D E, Brown M J

出版信息

J Neuroimmunol. 1982 Jun;2(3-4):331-6. doi: 10.1016/0165-5728(82)90065-0.

Abstract

We confirmed earlier observations that experimental allergic neuritis (EAN) in Lewis rats induced by injection of bovine peripheral nerve myelin in complete Freund's adjuvant is not accompanied by development of experimental allergic encephalomyelitis. However, sera of these animals contained elevated titers of antibodies against central nervous system myelin basic protein (BP), likely induced by peripheral nerve P1 protein. Anti-BP antibodies were not seen in sera of rats with EAN induced by peripheral nerve P2 protein. Lack of encephalogenicity of bovine myelin in Lewis rats does not reflect simply lack of immune responses induced against BP.

摘要

我们证实了早期的观察结果，即通过在完全弗氏佐剂中注射牛周围神经髓磷脂诱导的Lewis大鼠实验性变应性神经炎（EAN），并不伴有实验性变应性脑脊髓炎的发生。然而，这些动物的血清中抗中枢神经系统髓磷脂碱性蛋白（BP）抗体的滴度升高，可能是由周围神经P1蛋白诱导产生的。在由周围神经P2蛋白诱导的EAN大鼠血清中未发现抗BP抗体。牛髓磷脂在Lewis大鼠中缺乏致脑炎性，这不仅仅反映了针对BP诱导的免疫反应的缺乏。