Lele A S, Carmody P J, Hurd M E, O'Leary J A
Obstet Gynecol. 1982 Jul;60(1):60-4.
The frequency of diagnostic amniocentesis is increasing. Fetal bleeding and trauma have long been recognized to be complications of amniocentesis. For detection of fetomaternal bleeding, efficacy of modified Kleihauer-Betke staining and alpha-fetoprotein elevation in maternal blood was assessed. Preamniocentesis ultrasound scanning was found useful in reducing the incidence of fetomaternal bleeding and bloody taps. Elevation of alpha-fetoprotein was found to be a more sensitive indicator of fetomaternal bleeding than was modified Kleihauer-Betke staining. The use of alpha-fetoprotein to detect fetomaternal bleeding associated with amniocentesis is suggested for the identification of Rh-negative patients requiring anti-D gamma-globulin to prevent sensitization.
诊断性羊膜穿刺术的频率正在增加。胎儿出血和创伤长期以来一直被认为是羊膜穿刺术的并发症。为了检测母胎出血，评估了改良的克-贝染色法和母血中甲胎蛋白升高的有效性。发现羊膜穿刺术前超声扫描有助于降低母胎出血和血性穿刺的发生率。发现甲胎蛋白升高是比改良的克-贝染色法更敏感的母胎出血指标。建议使用甲胎蛋白检测与羊膜穿刺术相关的母胎出血，以识别需要抗-Dγ球蛋白以预防致敏的Rh阴性患者。
