Pastore G, Cordero di Montezemolo L, Grazia G, Bracco G, Canavese F, Felicioni V, Trada M, Madon E
Pediatr Med Chir. 1981 Mar-Jun;3(2-3):213-8.
Six children with yolk sac tumor, 3 occurring in gonadal sites and 3 in extragonadal ones, were studied with respect to pathological features, laboratory findings and clinical course. Their histological appearance was similar regardless of the site of origin. The prognosis was poor, but all the cases exhibited objective response to chemotherapy. Two children are alive and off therapy from 27 and 60 months. Three of the six patients in which serum alfa-fetoprotein determinations were performed showed positive results. The demonstration of alfa-fetoprotein in the serum of these patients could prove to be of prognostic value, indicating the presence of residual or recurrent disease. It is advisable to gather cases from many Institutions in order to specify prognostic factors, to know the natural history of this tumor and to prepare an effective therapeutic program.
对6例卵黄囊瘤患儿进行了研究，其中3例发生于性腺部位，3例发生于性腺外部位，研究内容包括病理特征、实验室检查结果及临床病程。无论肿瘤起源部位如何，其组织学表现相似。预后较差，但所有病例对化疗均有客观反应。2例患儿存活，分别已停止治疗27个月和60个月。6例患者中有3例进行了血清甲胎蛋白测定，结果呈阳性。这些患者血清中甲胎蛋白的检测结果可能具有预后价值，提示存在残留或复发性疾病。为了明确预后因素、了解该肿瘤的自然史并制定有效的治疗方案，建议从多个机构收集病例。
