在携带HLA - A28的淋巴细胞上检测到两种不同的公共特异性。

Detection of two distinct public specificities on HLA-A28 bearing lymphocytes.

作者信息

Oldfather J W, Gebel H M, Holmes D J, Rodey G E

出版信息

Tissue Antigens. 1983 Jul;22(1):16-23. doi: 10.1111/j.1399-0039.1983.tb01159.x.

DOI:10.1111/j.1399-0039.1983.tb01159.x

PMID:6193603

Abstract

We have used the antiglobulin augmented cytotoxicity assay and platelet absorption-elution techniques to investigate crossreactivity among certain antigens coded by the HLA-A locus. These serologic and absorption studies demonstrated two supertypic determinants, distinct from private determinants, associated with HLA-A locus gene products. One determinant was present on HLA-A2, Aw23, Aw24, and A28 bearing lymphocytes; the other was found on HLA-A28, Aw33, Aw34, and A26 bearing lymphocytes. The second determinant was not associated with HLA-A25. Both supertypic determinants are associated with HLA-A28.

摘要

我们运用抗球蛋白增强细胞毒性试验和血小板吸收-洗脱技术，来研究由HLA - A位点编码的某些抗原之间的交叉反应性。这些血清学和吸收研究表明，存在两个超型决定簇，与个体特异性决定簇不同，它们与HLA - A位点基因产物相关。一个决定簇存在于携带HLA - A2、Aw23、Aw24和A28的淋巴细胞上；另一个则在携带HLA - A28、Aw33、Aw34和A26的淋巴细胞上被发现。第二个决定簇与HLA - A25不相关。两个超型决定簇均与HLA - A28相关。