Linnoila M, Karoum F, Potter W Z
Arch Gen Psychiatry. 1982 May;39(5):513-6. doi: 10.1001/archpsyc.1982.04290050007002.
Effects of clorgyline on urinary excretion of norepinephrine, dopamine, tyramine, and their major metabolites, 5-hydroxyindoleacetic acid and phenylethylamine, were studied in four women who suffered from primary, bipolar affective disorder. All patients had rapid mood cycles and were nonresponsive to lithium carbonate. During placebo administration, a strong correlation was found between the excretion rates of norepinephrine and dopamine and their respective metabolites. Clorgyline, 5 to 10 mg every or every other day, reduced overall-body norepinephrine turnover by 55% and increased tyramine but did not alter 5-hydroxyindoleacetic acid, phenylethylamine, or p-hydroxyphenylacetic acid excretion. These findings demonstrate the clinical actions of low-dose clorgyline and clorgyline's specificity as a monoamine oxidase A (MAO-A) inhibitor in vivo in humans, as well as the effects of specific MAO-A inhibition on monoamine metabolism.
研究了氯吉兰对4名患有原发性双相情感障碍女性的去甲肾上腺素、多巴胺、酪胺及其主要代谢产物5-羟吲哚乙酸和苯乙胺尿排泄的影响。所有患者情绪波动迅速，对碳酸锂无反应。在服用安慰剂期间，发现去甲肾上腺素和多巴胺的排泄率与其各自代谢产物之间存在强烈相关性。氯吉兰，每隔一天或每天5至10毫克，可使全身去甲肾上腺素周转率降低55%，并增加酪胺，但不改变5-羟吲哚乙酸、苯乙胺或对羟基苯乙酸的排泄。这些发现证明了低剂量氯吉兰的临床作用及其作为单胺氧化酶A（MAO-A）抑制剂在人体内的特异性，以及特异性MAO-A抑制对单胺代谢的影响。
