Potter W Z, Murphy D L, Wehr T A, Linnoila M, Goodwin F K
Arch Gen Psychiatry. 1982 May;39(5):505-10. doi: 10.1001/archpsyc.1982.04290050001001.
Five women with primary, major, bipolar affective disorder, characterized by rapid mood cycles and nonresponsiveness to conventional drug treatments, including lithium carbonate, were given low doses (2.5 to 10.0 mg/24 hr) of clorgyline, a selective inhibitor of monoamine oxidase type A. In four patients, clorgyline, along or in combination with lithium carbonate, prolonged the duration and lessened the severity of mood cycles. One patient experienced prolonged mania while receiving clorgyline therapy. Clorgyline-induced remissions have lasted from three to more than 12 months.
五名患有原发性重度双相情感障碍的女性，其特点是情绪快速循环且对包括碳酸锂在内的传统药物治疗无反应，她们接受了低剂量（2.5至10.0毫克/24小时）的氯吉兰，一种A型单胺氧化酶的选择性抑制剂。在四名患者中，氯吉兰单独使用或与碳酸锂联合使用，延长了情绪循环的持续时间并减轻了其严重程度。一名患者在接受氯吉兰治疗时经历了长时间的躁狂发作。氯吉兰诱导的缓解期持续了三至超过十二个月。
