β2微球蛋白特异性自身抗体可导致血小板聚集，并干扰二磷酸腺苷诱导的聚集。
Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation.
作者信息
Falus A, Merétey K, Bagdy D, Diószegi M, Böhm U, Csák E, Bozsóky S
出版信息
Clin Exp Immunol. 1982 Jan;47(1):103-9.
Abstract
The anti-platelet activity of beta-2-microglobulin (beta 2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays. It was established that human anti-beta 2m autoantibodies and heterologous rabbit anti-beta 2m antibodies evoke a dose-dependent aggregation of human platelets. Anti-beta 2m autoantibodies also impaired ADP-induced platelet aggregation. Antibodies with anti-beta 2m activity could be desorbed from the platelets and lymphocytes of a patients with systemic lupus erythematosus who was not thrombocytopenic. The possibility that such autoantibodies may alter platelet function is considered.
摘要
从自身免疫性疾病患者血清中分离出的β2微球蛋白（β2m）特异性自身抗体的抗血小板活性，在直接和ADP诱导的聚集试验中进行了检测。结果表明，人抗β2m自身抗体和异源兔抗β2m抗体可引起人血小板的剂量依赖性聚集。抗β2m自身抗体也会损害ADP诱导的血小板聚集。具有抗β2m活性的抗体可从一名非血小板减少的系统性红斑狼疮患者的血小板和淋巴细胞中解吸附出来。人们考虑了这种自身抗体可能改变血小板功能的可能性。
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Clin Immunol Immunopathol. 1980 Jan;15(1):1-10. doi: 10.1016/0090-1229(80)90015-x.
3
Prevalence of anti-beta-2 microglobulin autoantibodies in sera of rheumatoid arthritis patients with extra-articular manifestations.有关节外表现的类风湿关节炎患者血清中抗β2微球蛋白自身抗体的患病率
Ann Rheum Dis. 1981 Aug;40(4):409-13. doi: 10.1136/ard.40.4.409.
4
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