有关节外表现的类风湿关节炎患者血清中抗β2微球蛋白自身抗体的患病率
Prevalence of anti-beta-2 microglobulin autoantibodies in sera of rheumatoid arthritis patients with extra-articular manifestations.
作者信息
Falus A, Merétey K, Bozsóky S
出版信息
Ann Rheum Dis. 1981 Aug;40(4):409-13. doi: 10.1136/ard.40.4.409.
Abstract
The frequency and concentration of specific factors binding beta 2 microglobulin were investigated in sera and synovial fluids of patients and in sera of normal controls. High anti-beta 2 m activity was detected in the sera of adult RA patients, particularly in those of with extra-articular disease. Similarly, anti-beta 2 m was present in the synovial fluids of RA but not of osteoarthrosis patients. Both the binding of anti-beta 2 m activity to the Sepharose staphylococcal protein A and its elution position in the second 'IgG' peak after Sephadex G-200 gel filtration suggest the antibody nature of the activity. The possibility of differences not only in titre but also in the specificity of heterologous and homologous anti-beta 2 m antibodies are discussed.
摘要
研究了患者血清和滑液以及正常对照血清中与β2微球蛋白结合的特定因子的频率和浓度。在成年类风湿性关节炎（RA）患者的血清中检测到高抗β2m活性，尤其是在那些患有关节外疾病的患者中。同样，抗β2m存在于RA患者的滑液中，而骨关节炎患者的滑液中则不存在。抗β2m活性与琼脂糖葡萄球菌蛋白A的结合及其在Sephadex G - 200凝胶过滤后的第二个“IgG”峰中的洗脱位置均表明该活性具有抗体性质。文中讨论了异源和同源抗β2m抗体不仅在滴度上而且在特异性上存在差异的可能性。
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本文引用的文献
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J Biol Chem. 1951 Nov;193(1):265-75.
2
STANDARDIZATION OF THE SHEEP CELL AGGLUTINATION TEST. THE USE OF POOLED REFERENCE SERA AND HEMAGGLUTINATION TRAYS.绵羊细胞凝集试验的标准化。混合参考血清和血凝板的使用。
Arthritis Rheum. 1965 Aug;8:530-7. doi: 10.1002/art.1780080407.
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Analysis of immune complexes in synovial effusions of patients with rheumatoid arthritis.类风湿关节炎患者滑膜积液中免疫复合物的分析。
Clin Exp Immunol. 1980 Feb;39(2):297-306.
4
The serum levels and urinary excretion of 2 -microglobulin in apparently healthy subjects.健康受试者血清中β2微球蛋白水平及尿排泄情况。
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