Lucero M A, Magdelenat H, Fridman W H, Pouillart P, Billardon C, Billiau A, Cantell K, Falcoff E
Eur J Cancer Clin Oncol. 1982 Mar;18(3):243-51. doi: 10.1016/0277-5379(82)90043-8.
Patients with metastatic cancer were given single intramuscular injections of 10(7) units of partially purified preparations of either leukocyte or fibroblast IFN. Serum levels of inteferon, of beta 2-microglobulin and of carcino-embryonic antigen (CEA), as well as NK activity of circulating lymphocyte, were followed over a period of 96 hr post injection. In confirmation of previous studies, levels of circulating IFN were lower after injection of fibroblast IFN than after injection of leukocyte IFN. Despite this difference in pharmacokinetics, the natural killer activity of circulating lymphocytes was enhanced with both IFNs. Levels of DEA were not influenced by the IFN injections. Leukocyte but not fibroblast IFN caused an increase in serum levels of beta 2-microglobulin in the circulation. A similar difference between leukocyte and fibroblast IFN in their ability to influence the beta 2-microglubulin system was observed in experiments on cell cultures. Only leukocyte IFN was able to cause release of beta 2-microglobulin by either leukocytes or fibroblasts.
给转移性癌症患者单次肌内注射10⁷单位的白细胞或成纤维细胞干扰素部分纯化制剂。在注射后96小时内，跟踪检测血清中干扰素、β2-微球蛋白和癌胚抗原（CEA）的水平，以及循环淋巴细胞的自然杀伤活性。正如先前研究所证实的，注射成纤维细胞干扰素后循环干扰素水平低于注射白细胞干扰素后。尽管在药代动力学上存在这种差异，但两种干扰素均可增强循环淋巴细胞的自然杀伤活性。干扰素注射对CEA水平没有影响。白细胞干扰素而非成纤维细胞干扰素可导致循环中血清β2-微球蛋白水平升高。在细胞培养实验中，观察到白细胞干扰素和成纤维细胞干扰素在影响β2-微球蛋白系统能力方面存在类似差异。只有白细胞干扰素能够促使白细胞或成纤维细胞释放β2-微球蛋白。
