体内人干扰素刺激后人类单核细胞HLA - DR抗原及Fcγ受体表达增加。
Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.
作者信息
Rhodes J, Jones D H, Bleehen N M
出版信息
Clin Exp Immunol. 1983 Sep;53(3):739-43.
Abstract
The expression of class II MHC encoded antigens (HLA-DR) and Fc gamma receptors by peripheral blood monocytes from untreated patients with small cell carcinoma of the bronchus was compared with that of normal donors. Fc gamma receptor expression was found to be elevated in these patients in comparison with normal. In contrast HLA-DR antigen expression by patients' monocytes was somewhat depressed in comparison with normal. Continuous intravenous infusion of a total of 400 megaunits/m2 of human lymphoblastoid interferon-alpha (IFN-alpha) over a 5 day period markedly increased both monocyte HLA-DR antigen expression and Fc gamma receptor expression in comparison with that of untreated patients and normal donors. The initial increases declined somewhat but were still evident after 3 weeks of intermittent intramuscular IFN-alpha therapy.
摘要
将未经治疗的支气管小细胞癌患者外周血单核细胞的II类主要组织相容性复合体（MHC）编码抗原（HLA - DR）和Fcγ受体的表达与正常供体进行了比较。发现这些患者的Fcγ受体表达相对于正常情况有所升高。相比之下，患者单核细胞的HLA - DR抗原表达相对于正常情况有所降低。在5天内连续静脉输注总共400万单位/平方米的人淋巴母细胞干扰素α（IFN - α），与未经治疗的患者和正常供体相比，显著增加了单核细胞HLA - DR抗原表达和Fcγ受体表达。最初的增加有所下降，但在间歇性肌肉注射IFN - α治疗3周后仍很明显。
相似文献
1
Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivo.体内人干扰素刺激后人类单核细胞HLA - DR抗原及Fcγ受体表达增加。
Clin Exp Immunol. 1983 Sep;53(3):739-43.
2
3
Pure interferon gamma enhances class II HLA antigens on human monocyte cell lines.纯γ干扰素可增强人单核细胞系上的II类HLA抗原。
Eur J Immunol. 1984 Jan;14(1):106-8. doi: 10.1002/eji.1830140120.
4
IL-10 augments CD23 expression on U937 cells and down-regulates IL-4-driven CD23 expression on cultured human blood monocytes: effects of IL-10 and other cytokines on cell phenotype and phagocytosis.白细胞介素-10增强U937细胞上CD23的表达，并下调白细胞介素-4驱动的培养人血单核细胞上CD23的表达：白细胞介素-10和其他细胞因子对细胞表型和吞噬作用的影响。
Immunology. 1995 Jun;85(2):311-7.
5
Inhibition of human monocyte Fc receptor and HLA-DR antigen expression by pregnancy alpha-2 glycoprotein.妊娠α-2糖蛋白对人单核细胞Fc受体和HLA-DR抗原表达的抑制作用。
Clin Exp Immunol. 1981 Nov;46(2):350-4.
6
Altered phagocytosis by monocytes from HLA-DR2 and DR3-positive healthy adults is Fc gamma receptor specific.来自HLA - DR2和DR3阳性健康成年人的单核细胞吞噬作用的改变具有Fcγ受体特异性。
J Immunol. 1986 May 15;136(10):3625-30.
7
8
Quantification of macrophage cell surface molecules in rheumatoid arthritis.类风湿关节炎中巨噬细胞表面分子的定量分析。
Clin Exp Immunol. 1989 Jul;77(1):47-51.
9
Recombinant interferon-gamma increases HLA-DR synthesis and expression.重组干扰素-γ可增加HLA-DR的合成与表达。
J Immunol. 1983 Apr;130(4):1492-4.
10
Regulation of HLA-DR and invariant chain expression by human peripheral blood mononuclear cells with lead, interferon-gamma, or interleukin-4.铅、干扰素-γ或白细胞介素-4对人外周血单个核细胞HLA-DR及恒定链表达的调控
Cell Immunol. 1996 Jul 10;171(1):1-9. doi: 10.1006/cimm.1996.0166.
引用本文的文献
1
The role of type I interferon signaling in myeloid anti-tumor immunity.I型干扰素信号在髓系抗肿瘤免疫中的作用。
Front Immunol. 2025 Mar 3;16:1547466. doi: 10.3389/fimmu.2025.1547466. eCollection 2025.
2
Serum cytokines associated with severity and complications of kala-azar.血清细胞因子与黑热病的严重程度和并发症相关。
Pathog Glob Health. 2013 Mar;107(2):78-87. doi: 10.1179/2047773213Y.0000000078.
3
Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-α or TLR-9 agonist and GM-CSF with peptide vaccination.转移性黑色素瘤患者接受抗 CTLA-4 抗体和干扰素-α或 TLR-9 激动剂及 GM-CSF 与肽疫苗联合治疗时循环调节性 T 细胞和髓源抑制细胞的不同模式。
J Immunother. 2012 Nov-Dec;35(9):702-10. doi: 10.1097/CJI.0b013e318272569b.
4
Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients.肾移植受者丙型肝炎病毒感染治疗的疗效和安全性。
World J Gastroenterol. 2012 Jan 7;18(1):55-63. doi: 10.3748/wjg.v18.i1.55.
5
Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon.接受α干扰素治疗的肝移植受者急性移植物排斥反应的发生率和严重程度。
Liver Transpl Surg. 1998 May;4(3):197-203. doi: 10.1002/lt.500040315.
6
Human tumour-induced inhibition of interferon action in vitro: reversal of inhibition by beta-carotene (pro-vitamin A).人肿瘤诱导的体外干扰素作用抑制：β-胡萝卜素（维生素A原）对抑制作用的逆转
Cancer Immunol Immunother. 1984;16(3):189-92. doi: 10.1007/BF00205428.
7
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide.
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8686-90. doi: 10.1073/pnas.82.24.8686.
8
Enhancement of monocyte class I and II histocompatibility antigen expression in man by in vivo beta-interferon.体内β-干扰素增强人体单核细胞I类和II类组织相容性抗原表达
Clin Exp Immunol. 1987 Jul;69(1):107-15.
9
10
Human macrophage activation. Modulation of mannosyl, fucosyl receptor activity in vitro by lymphokines, gamma and alpha interferons, and dexamethasone.人类巨噬细胞活化。淋巴因子、γ干扰素、α干扰素及地塞米松对体外甘露糖基、岩藻糖基受体活性的调节作用。
J Clin Invest. 1985 Feb;75(2):624-31. doi: 10.1172/JCI111740.
本文引用的文献
1
Increased monocyte phagocytosis in cancer patients.
Eur J Cancer (1965). 1980 Oct;16(10):1315-20. doi: 10.1016/0014-2964(80)90288-1.
2
Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha.接受人α干扰素治疗的患者外周血单核细胞吞噬活性降低。
Cancer Immunol Immunother. 1982;13(3):149-52. doi: 10.1007/BF00205379.
3
Human lymphoblastoid interferon in the treatment of small cell lung cancer.人淋巴母细胞干扰素治疗小细胞肺癌
Br J Cancer. 1983 Mar;47(3):361-6. doi: 10.1038/bjc.1983.54.
4
Prostaglandins modulate macrophage Ia expression.前列腺素调节巨噬细胞Ia抗原的表达。
Nature. 1982 Sep 9;299(5879):163-5. doi: 10.1038/299163a0.
5
Isolation of an inhibitor of type II interferon induction from tumor ascitic fluids.从肿瘤腹水中分离出II型干扰素诱导抑制剂。
Cancer Res. 1980 Jul;40(7):2534-8.
6
Effect of retinoic acid on the spontaneous and interferon-induced activity of human natural killer cells.
Int J Cancer. 1982 Sep 15;30(3):307-10. doi: 10.1002/ijc.2910300309.
7
Comparison of effects of leukocyte and fibroblast interferon on immunological parameters in cancer patients.白细胞干扰素和成纤维细胞干扰素对癌症患者免疫参数影响的比较。
Eur J Cancer Clin Oncol. 1982 Mar;18(3):243-51. doi: 10.1016/0277-5379(82)90043-8.
8
Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid.干扰素诱导的单核细胞膜变化：视黄醇和视黄酸的抑制作用。
Immunology. 1982 Mar;45(3):531-6.
9
Retinoic acid: enhancement of a tumor and inhibition of interferon's antitumor action.
J Natl Cancer Inst. 1981 Jul;67(1):95-7.
10
A monoclonal antibody to the HLA-DR product recognizes a polymorphic Ia determinant in mice.一种针对HLA - DR产物的单克隆抗体识别小鼠中的一种多态性Ia决定簇。
Immunology. 1981 Jul;43(3):493-501.
Zotero 插件