Abreu S L
Immunol Commun. 1982;11(1):1-7. doi: 10.3109/08820138209050718.
Experimental allergic encephalomyelitis (EAE) is an experimental, T-cell dependent, autoimmune disease of the central nervous system that can be induced in most mammals by the injection of myelinated neural tissue in complete Freund's adjuvant. Relatively small doses, 10(4.6) Units/kg, of rat interferon (IFN), specific activity 10(7.6) Units/kg, delayed the onset of the disease and significantly ameliorated the severity of EAE symptoms observed in Lewis rats. Injection of IFN at 10(5.6) U/Kg suppressed hind limb paralysis in 70 to 80% of the rats.
实验性变态反应性脑脊髓炎（EAE）是一种实验性的、T细胞依赖性的中枢神经系统自身免疫性疾病，通过在完全弗氏佐剂中注射有髓神经组织，可在大多数哺乳动物中诱发该病。相对小剂量（10⁴·⁶单位/千克）、比活性为10⁷·⁶单位/千克的大鼠干扰素，可延迟疾病的发作，并显著改善在刘易斯大鼠中观察到的EAE症状的严重程度。以10⁵·⁶单位/千克的剂量注射干扰素，可使70%至80%的大鼠后肢麻痹得到抑制。
