Abreu S L, Tondreau J, Levine S, Sowinski R
Int Arch Allergy Appl Immunol. 1983;72(1):30-3. doi: 10.1159/000234836.
Recently it has been reported that interferon (IFN) suppresses experimental allergic encephalomyelitis (EAE) in actively immunized Lewis rats. In the present study the effect of IFN on a localized form of passively transferred EAE has been investigated. Localization and acceleration of the disease was obtained by injection of EAE lymph node cells into rats which had, 3 days previously, been prepared with a thermal brain injury. Within 24 h of cell transfer perivenular lymphocytic infiltrates (EAE lesions) were observed in the brain. Administration of IFN (40,000 U/kg) right after EAE lymph node cell injection resulted in a significant reduction or elimination of EAE lesions. The possibility that IFN is acting exclusively on the afferent arc is eliminated, and the results suggest that IFN may be acting, although not solely, through modulations of components of the efferent arc. IFN was equally effective in suppressing EAE in adrenalectomized animals. This demonstrates that the immunosuppressive effects observed in this study are not due to endogenously produced corticosteroids.
最近有报道称，干扰素（IFN）可抑制主动免疫的Lewis大鼠的实验性变应性脑脊髓炎（EAE）。在本研究中，已对IFN对局部形式的被动转移EAE的作用进行了研究。通过将EAE淋巴结细胞注射到3天前已造成热脑损伤的大鼠体内，实现了疾病的定位和加速。在细胞转移后24小时内，在脑中观察到血管周围淋巴细胞浸润（EAE病变）。在注射EAE淋巴结细胞后立即给予IFN（40,000 U/kg），导致EAE病变显著减少或消除。IFN仅作用于传入弧的可能性被排除，结果表明IFN可能起作用，尽管不是唯一地，通过调节传出弧的成分。IFN在抑制肾上腺切除动物的EAE方面同样有效。这表明在本研究中观察到的免疫抑制作用不是由于内源性产生的皮质类固醇。
