Norlén L, Sundin T
Int Rehabil Med. 1982;4(1):37-43. doi: 10.3109/03790798209166821.
The morphology of the adrenergic nervous systems as well as adrenoceptor functions of the human lower urinary tract are outlined and compared to some animal studies. Special emphasis is given to the altered adrenergic innervation and adrenoceptor function after parasympathetic decentralization. Pharmacological treatment affecting adrenoceptors is described in different disturbances of lower urinary tract function and some evidence for adrenergic mechanisms working in intravaginal electrical stimulation is presented. The importance of the sympathetic nervous system for the normal function of the human lower urinary tract is still unclear. Nevertheless, clinical data obtained by treatment with agents influencing this system indicate that the contractory alpha-adrenoceptors of the human urethra can be stimulated or blocked pharmacologically producing significant changes in intraurethral pressure. On the other hand, the relaxatory effect on the human detrusor obtained by stimulation of the beta-adrenoceptors seems to be negligible.
概述了人类下尿路肾上腺素能神经系统的形态以及肾上腺素能受体功能，并与一些动物研究进行了比较。特别强调了副交感神经去传入后肾上腺素能神经支配和肾上腺素能受体功能的改变。描述了影响肾上腺素能受体的药物治疗在不同下尿路功能障碍中的应用，并提出了阴道内电刺激中肾上腺素能机制起作用的一些证据。交感神经系统对人类下尿路正常功能的重要性仍不清楚。然而，通过使用影响该系统的药物进行治疗所获得的临床数据表明，人类尿道的收缩性α-肾上腺素能受体可以通过药物刺激或阻断，从而使尿道内压产生显著变化。另一方面，刺激β-肾上腺素能受体对人类逼尿肌的松弛作用似乎可以忽略不计。
