Mattiasson A, Andersson K E, Elbadawi A, Morgan E, Sjögren C
J Urol. 1987 May;137(5):1017-9. doi: 10.1016/s0022-5347(17)44350-3.
The influence of muscarinic receptor stimulation (carbachol) and blockade (scopolamine) on the release of 3H-labelled noradrenaline from adrenergic neurons was investigated in isolated detrusor preparations from rabbit, cat and man. A significant influence on the release of 3H from adrenergic nerve terminals was found in the three species with a concentration-dependent decrease and increase induced by carbachol and scopolamine, respectively. Using the alpha 2-adrenoceptor stimulating and blocking agents clonidine and rauwolscine in rabbit and human detrusor preparations, the presence of prejunctionally located inhibitory alpha 2-adrenoceptors could also be demonstrated. The findings indicate the possibility of a functionally important interaction between cholinergic and adrenergic nerves in the urinary bladder mediated via inhibitory muscarinic receptors on adrenergic nerve terminals.
在兔、猫和人的离体逼尿肌制备物中，研究了毒蕈碱受体刺激剂（卡巴胆碱）和阻滞剂（东莨菪碱）对肾上腺素能神经元释放³H标记去甲肾上腺素的影响。在这三个物种中均发现，卡巴胆碱和东莨菪碱分别诱导³H从肾上腺素能神经末梢的释放呈浓度依赖性减少和增加，对其释放有显著影响。在兔和人的逼尿肌制备物中使用α₂-肾上腺素能受体激动剂和拮抗剂可乐定和育亨宾，也证实了突触前存在抑制性α₂-肾上腺素能受体。这些发现表明，膀胱中胆碱能神经和肾上腺素能神经之间可能通过肾上腺素能神经末梢上的抑制性毒蕈碱受体介导功能上重要的相互作用。
