Gil A, Sanchez-Medina F
J Dairy Res. 1982 May;49(2):301-7. doi: 10.1017/s0022029900022391.
The acid-soluble ribonucleotides of human milk were measured by enzymic and ion-exchange chromatographic procedures at different stages of lactation. Human colostrum and milk contained CMP, AMP, GMP, UMP, GDP-mannose, UDP-N-acetyl-glucosamine, UDP-N-acetyl-galactosamine, UDP-glucose, UDP-galactose, UDP and other minor nucleotides. Cytidine and adenosine derivatives were present in relatively higher amounts than in milk from ruminant species. The nucleotide concentration decreased with advancing lactation. Human milk at 3 months of lactation contained about 10 mumol/100 ml nucleotides, which represented about 75% of the amount of nucleotides present in human colostrum. Human milk did not contain orotic acid. The UDP-glucose/UDP-galactose ratio was constant during lactation and was similar to that of milks from ruminant species.
采用酶法和离子交换色谱法，对人乳在不同泌乳阶段的酸溶性核糖核苷酸进行了测定。人初乳和乳汁中含有胞苷一磷酸（CMP）、腺苷一磷酸（AMP）、鸟苷一磷酸（GMP）、尿苷一磷酸（UMP）、二磷酸鸟苷甘露糖（GDP-甘露糖）、二磷酸尿苷-N-乙酰葡糖胺（UDP-N-乙酰葡糖胺）、二磷酸尿苷-N-乙酰半乳糖胺（UDP-N-乙酰半乳糖胺）、二磷酸尿苷葡萄糖（UDP-葡萄糖）、二磷酸尿苷半乳糖（UDP-半乳糖）、二磷酸尿苷（UDP）及其他少量核苷酸。与反刍动物的乳汁相比，人初乳和乳汁中胞嘧啶和腺苷衍生物的含量相对较高。核苷酸浓度随着泌乳进程而降低。产后3个月的人乳中核苷酸含量约为10 μmol/100 ml，约占人初乳中核苷酸含量的75%。人乳中不含乳清酸。泌乳期间，UDP-葡萄糖/UDP-半乳糖的比值恒定，且与反刍动物乳汁的该比值相似。
