Cosgrove M, Davies D P, Jenkins H R
Department of Child Health, University of Wales College of Medicine, Heath Park, Cardiff.
Arch Dis Child Fetal Neonatal Ed. 1996 Mar;74(2):F122-5. doi: 10.1136/fn.74.2.f122.
A double blind randomised controlled trial in small for gestational age (SGA) infants, whose intestinal mucosa was shown to be functionally impaired as a result of intrauterine undernutrition, was carried out to investigate the hypothesis that nucleotide supplementation of a milk formula could improve catchup growth. Anthropometric data were collected on 74 infants, 39 randomly allocated to the nucleotide supplemented group (group N) and 35 to a standard formula group (group S). From study entry to 2 months of age, infants in group N had significantly higher mean rates of weight gain (106.3 compared with 94.7 g/kg baseline weight/week) and length gain (21.8 v 19.7 mm/m baseline length/week). Over the whole six months for which the trial formula was provided group N had significantly higher mean rates of gain of weight (80.1 compared with 71.8 g/kg baseline weight/week), length (16.2 compared with 15.0 mm/m baseline length/week), and head circumference (11.8 compared with 10.8 mm/m baseline head circumference/week). Catchup growth in SGA infants is therefore improved by nucleotide supplementation of infant formula.
在小于胎龄儿（SGA）中进行了一项双盲随机对照试验，这些婴儿的肠黏膜因宫内营养不良而出现功能受损，该试验旨在研究在婴儿配方奶粉中添加核苷酸可促进追赶生长这一假设。收集了74名婴儿的人体测量数据，其中39名被随机分配到添加核苷酸组（N组），35名被分配到标准配方奶粉组（S组）。从研究开始到2月龄，N组婴儿的平均体重增加率（相对于基线体重每周106.3克，而S组为94.7克/千克）和身长增加率（相对于基线身长每周21.8毫米，而S组为19.7毫米/米）显著更高。在提供试验配方奶粉的整个六个月期间，N组的平均体重增加率（相对于基线体重每周80.1克，而S组为71.8克/千克）、身长增加率（相对于基线身长每周16.2毫米，而S组为15.0毫米/米）和头围增加率（相对于基线头围每周11.8毫米，而S组为10.8毫米/米）均显著更高。因此，在婴儿配方奶粉中添加核苷酸可改善SGA婴儿的追赶生长。
