麻风病中的电泳和免疫电泳

Electrophoresis and immuno electrophoresis in leprosy.

作者信息

Saoji A, Mene A, Sharma K D

出版信息

Lepr India. 1978 Apr;50(2):161-5.

Abstract

50 cases of leprosy belonging to various subgroups i.e. 10 tuberculoid, 25 lepromatous leprosy, 10 lepra reaction, 5 dimorphic leprosy, and 25 cases or normal individuals were subjected to agar gel electrophoresis. The slides were scanned by densitometry. It showed profound departure from normal in various fractions of electrophoretic patterns. All of them showed rise of gamma globulin. Albumin was markedly decreased in lepromotous leprosy and lepra reaction. In dimorphic leprosy Alfa-1 was decreased. Qualitative immuno electrophoresis was done by using antihuman serum raised in the laboratory, by immunising rabbits. It revealed changes in IgM and IgG arcs. Results are discussed and tried to explain on immunological derangement.

摘要

50例属于不同亚组的麻风病患者，即10例结核样型、25例瘤型麻风、10例麻风反应、5例混合型麻风，以及25例正常个体接受了琼脂凝胶电泳。通过光密度测定法对玻片进行扫描。结果显示，电泳图谱的各个组分与正常情况有显著差异。所有患者的γ球蛋白均升高。瘤型麻风及麻风反应患者的白蛋白明显降低。混合型麻风患者的α-1降低。通过用在实验室中免疫兔子制备的抗人血清进行定性免疫电泳。结果显示IgM和IgG弧出现变化。对结果进行了讨论，并试图从免疫紊乱的角度进行解释。