麻风病中的免疫球蛋白

Gupta R M, Gupta S C, Singh G, Khanna S

Int J Lepr Other Mycobact Dis. 1978 Jul-Dec;46(3-4):342-5.

Serum immunoglobulins IgG, IgA and IgM were estimated in 22 lepromatous (LL) patients, 28 tuberculoid (TT), 9 borderline tuberculoid (BT), and 8 borderline lepromatous (BL), and compared with 50 normal healthy adult males belonging to a low socio-economic class. Immunoglobulin IgM was invariably significantly raised in TT, BT and LL subgroups of leprosy patients compared to the control but variation among different subgroups was statistically insignificant. Mean serum IgA levels were also raised in TT, BL and LL subgroups but statistically the rise was not significant. In the BT subgroup, significantly low IgA levels were observed both compared to the control and the other leprosy subgroups. Immunoglobulin G levels were significantly raised only in the LL subgroups compared to the control and the other subgroups of leprosy patients. It is proposed that persistently raised gamma globulins and immunoglobulin G, A and M levels observed in lepromatous leprosy patients could be caused by macrophage blockade hindering the suppressor T-cell mediated homeostatic control for immunoglobulins.

对22例瘤型麻风（LL）患者、28例结核样型麻风（TT）患者、9例界线类偏结核样型麻风（BT）患者和8例界线类偏瘤型麻风（BL）患者的血清免疫球蛋白IgG、IgA和IgM进行了测定，并与50名社会经济地位较低的正常健康成年男性进行了比较。与对照组相比，麻风患者的TT、BT和LL亚组中免疫球蛋白IgM始终显著升高，但不同亚组之间的差异无统计学意义。TT、BL和LL亚组的平均血清IgA水平也有所升高，但在统计学上升高并不显著。在BT亚组中，与对照组和其他麻风亚组相比，均观察到IgA水平显著降低。与对照组和其他麻风患者亚组相比，仅LL亚组的免疫球蛋白G水平显著升高。有人提出，瘤型麻风患者中持续升高的γ球蛋白以及免疫球蛋白G、A和M水平可能是由于巨噬细胞阻滞阻碍了抑制性T细胞介导的免疫球蛋白稳态控制所致。