Matsumoto K, Osakabe K, Katayama H, Fujita T, Takazawa M, Tochihara K, Harada M, Hatano M
Nephron. 1982;30(3):205-9. doi: 10.1159/000182463.
Leukocyte adherence inhibition (LAI) test was examined in 35 patients with renal diseases and 14 normal controls, using collagenase-treated glomerular basement membrane, glycosidase-treated glomerular basement membrane and renal tubular epithelium as antigens. Although the control group showed strikingly similar mean LAI indices for all antigens tested, the whole group of patients with renal diseases showed a wide scatter of values. Two categories of patients had significantly increased LAI indices (p less than 0.01) when their mean values were compared with those of normal controls: (1) rapidly progressive glomerulonephritis (RPGN) and (2) lupus nephritis (SLE). In the serial studies of the RPGN and SLE cases, there were no significant changes in the pattern of LAI and they continued to give positive and very comparable results when re-examined at intervals of 1-6 months. Out of the 30 patients who were able to be evaluated with the three antigens, 15 cases exhibited positive LAI response to two or more antigens simultaneously. These in vitro findings suggest that there is an abnormal cellular response to certain antigen or widespread LAI reactivity to a variety of renal antigens in certain forms of human glomerulonephritis.
采用经胶原酶处理的肾小球基底膜、经糖苷酶处理的肾小球基底膜和肾小管上皮作为抗原，对35例肾病患者和14名正常对照者进行了白细胞黏附抑制（LAI）试验。尽管对照组对所有测试抗原的平均LAI指数显示出惊人的相似性，但肾病患者的整个群体显示出广泛的数值离散。当将两类患者的平均值与正常对照者的平均值进行比较时，其LAI指数显著升高（p小于0.01）：（1）急进性肾小球肾炎（RPGN）和（2）狼疮性肾炎（SLE）。在对RPGN和SLE病例的系列研究中，LAI模式没有显著变化，并且当在1 - 6个月的间隔时间重新检查时，它们继续给出阳性且非常可比的结果。在能够用这三种抗原进行评估的30例患者中，15例同时对两种或更多种抗原表现出阳性LAI反应。这些体外研究结果表明，在某些形式的人类肾小球肾炎中，存在对某些抗原的异常细胞反应或对多种肾脏抗原的广泛LAI反应性。
